| Catalog Number | GTX101115 |
| Product Name | 8-oxoguanine DNA-glycosylase 1 isoform 2a antibody |
| Full Name | 8-oxoguanine DNA glycosylase |
| Product Description | Rabbit polyclonal antibody to OGG1 (8-oxoguanine DNA glycosylase) |
| Synonyms | HMMH | HOGG1 | MUTM | OGH1 |
| Background | This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq] |
| Clonality | Polyclonal |
| Host | Rabbit |
| Immunogen | Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 322 of Human OGG1 |
| Antigen Species | Human |
| Tested Applications | WB. The usefulness of this product in other applications has not been determined. |
| Application Note | Suggested starting dilutions are as follows. WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user. |
| Specificity | This antibody is specific to the Human OGG1 protein. |
| Species Cross Reactivity | Human - Not yet tested in other species |
| Positive Controls | Molt-4 |
| Target | OGG1 |
| Predicted Target Size(KDa) | 47.25 |
| Cellular Localization | Isoform 1A: Nucleus | Isoform 2A: Mitochondrion |
| Form Supplied | Liquid |
| Concentration | 1 mg/ml |
| Purification | Purified by antigen-affinity chromatography. |
| Storage Buffer | 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
| Storage Instruction | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Notes | For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |
Image:GTX101115 WB ImageSample (30 ug of whole cell lysate) A: Molt-4 (GTX27912) 10% SDS PAGE GTX101115 diluted at 1:1000 Print:Print
