| Catalog Number | GTX111418 |
| Product Name | AAK1 antibody |
| Full Name | AP2 associated kinase 1 |
| Product Description | Rabbit polyclonal antibody to AAK1 (AP2 associated kinase 1) |
| Synonyms | DKFZp686F03202 | DKFZp686K16132 | FLJ23712 | FLJ25931 | FLJ31060 | FLJ42882 | FLJ45252 | KIAA1048 | MGC138170 | MGC164568 | MGC164570 |
| Background | Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq] |
| Clonality | Polyclonal |
| Host | Rabbit |
| Immunogen | Recombinant protein fragment contain a sequence corresponding to a region within amino acids 63 and 274 of AAK1 |
| Antigen Species | Human |
| Tested Applications | Dot blot |
| Application Note | Further validation in progress. |
| Specificity | This antibody is specific to the Protein antigen from AAK1. |
| Species Cross Reactivity | Human - Not yet tested in other species |
| Positive Controls | Target recombinant protein |
| Target | AAK1 |
| Predicted Target Size(KDa) | 103.92 |
| Cellular Localization | Membrane; Peripheral membrane protein | Cell membrane; Peripheral membrane protein | Membrane | clathrin-coated pit | Membrane | Cell membrane | Membrane | clathrin-coated pit |
| Form Supplied | Liquid |
| Concentration | 1 mg/ml |
| Purification | Purified by antigen-affinity chromatography. |
| Storage Buffer | 0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
| Storage Instruction | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Notes | For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |
