| Catalog Number | GTX116022 |
| Product Name | ABC1 antibody |
| Full Name | ATP-binding cassette, sub-family A (ABC1), member 1 |
| Product Description | Rabbit polyclonal antibody to ABC1 (ATP-binding cassette, sub-family A (ABC1), member 1) |
| Synonyms | ABC-1 | ABC1 | CERP | FLJ14958 | HDLDT1 | MGC164864 | MGC165011 | TGD |
| Background | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangiers disease and familial high-density lipoprotein deficiency. [provided by RefSeq] |
| Clonality | Polyclonal |
| Host | Rabbit |
| Immunogen | Synthetic peptide contain a sequence corresponding to a region within amino acids 1836 and 1899 of ABC1 |
| Antigen Species | Human |
| Tested Applications | Dot blot |
| Application Note | Further validation in progress. |
| Specificity | This antibody is specific to the peptide antigen from ABC1 . |
| Species Cross Reactivity | Human - Not yet tested in other species |
| Positive Controls | Synthetic peptide: 1:8,000 |
| Target | ABC1 |
| Predicted Target Size(KDa) | 254.34 |
| Cellular Localization | Membrane |
| Form Supplied | Liquid |
| Concentration | 0.34 mg/ml |
| Purification | Purified by antigen-affinity chromatography. |
| Storage Buffer | 0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
| Storage Instruction | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Notes | For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |
