| Catalog Number | GTX108371 |
| Product Name | ABCA4 antibody |
| Full Name | ATP-binding cassette, sub-family A (ABC1), member 4 |
| Product Description | Rabbit polyclonal antibody to ABCA4 (ATP-binding cassette, sub-family A (ABC1), member 4) |
| Synonyms | ABC10 | ABCR | ARMD2 | CORD3 | DKFZp781N1972 | FFM | FLJ17534 | RMP | RP19 | STGD | STGD1 |
| Background | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease, a form of juvenile-onset macular degeneration. Mutations in this gene are also associated with retinitis pigmentosa-19, cone-rod dystrophy type 3, early-onset severe retinal dystrophy, fundus flavimaculatus, and macular degeneration age-related 2. [provided by RefSeq] |
| Clonality | Polyclonal |
| Host | Rabbit |
| Immunogen | Synthetic peptide contain a sequence corresponding to a region within amino acids 2210 and 2273 of Human ABCA4 |
| Antigen Species | Human |
| Tested Applications | Dot Blot |
| Application Note | Further validation in progress. |
| Specificity | This antibody is specific to the peptide antigen from ABCA4. |
| Species Cross Reactivity | Human - Not yet tested in other species |
| Positive Controls | Synthetic peptide: 1:8,000 |
| Target | ABCA4 |
| Predicted Target Size(KDa) | 255.98 |
| Cellular Localization | Membrane |
| Form Supplied | Liquid |
| Concentration | 0.55 mg/ml |
| Purification | Purified by antigen-affinity chromatography. |
| Storage Buffer | 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
| Storage Instruction | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Notes | For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |
