| Catalog Number | GTX105672 |
| Product Name | ABCD1 antibody |
| Full Name | ATP-binding cassette, sub-family D (ALD), member 1 |
| Product Description | Rabbit polyclonal antibody to ABCD1 (ATP-binding cassette, sub-family D (ALD), member 1) |
| Synonyms | ABC42 | ALD | ALDP | AMN |
| Background | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein is likely involved in the peroxisomal transport or catabolism of very long chain fatty acids. Defects in this gene have been identified as the underlying cause of adrenoleukodystrophy, an X-chromosome recessively inherited demyelinating disorder of the nervous system. [provided by RefSeq] |
| Clonality | Polyclonal |
| Host | Rabbit |
| Immunogen | Recombinant protein fragment contain a sequence corresponding to a region within amino acids 124 and 333 of Human ABCD1 |
| Antigen Species | Human |
| Tested Applications | Dot Blot |
| Application Note | Further validation in progress. |
| Specificity | This antibody is specific to the Protein antigen from ABCD1. |
| Species Cross Reactivity | Human - Not yet tested in other species |
| Positive Controls | Target recombinant protein |
| Target | ABCD1 |
| Predicted Target Size(KDa) | 82.95 |
| Cellular Localization | Peroxisome membrane |
| Form Supplied | Liquid |
| Concentration | 0.07 mg/ml |
| Purification | Purified by antigen-affinity chromatography. |
| Storage Buffer | 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
| Storage Instruction | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Notes | For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |
