| Catalog Number | GTX107868 |
| Product Name | ACK antibody |
| Full Name | tyrosine kinase, non-receptor, 2 |
| Product Description | Rabbit polyclonal antibody to ACK1 (tyrosine kinase, non-receptor, 2) |
| Synonyms | ACK | ACK1 | FLJ44758 | FLJ45547 | p21cdc42Hs |
| Background | This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq] |
| Clonality | Polyclonal |
| Host | Rabbit |
| Immunogen | Recombinant protein fragment contain a sequence corresponding to a region within amino acids 236 and 503 of Human ACK1 |
| Antigen Species | Human |
| Tested Applications | WB. The usefulness of this product in other applications has not been determined. |
| Application Note | Suggested starting dilutions are as follows. WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user. |
| Specificity | This antibody is specific to the Human ACK1 protein. |
| Species Cross Reactivity | Tested with Human antigen. Other species have not been tested. |
| Positive Controls | 293T |
| Target | ACK1 |
| Predicted Target Size(KDa) | 60.07 |
| Cellular Localization | Cell membrane |
| Form Supplied | Liquid |
| Concentration | 0.35 mg/ml |
| Purification | Purified by antigen-affinity chromatography. |
| Storage Buffer | 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
| Storage Instruction | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Notes | For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |
Image:GTX107868 WB ImageWestern Blot analysis of TNK2 expression in transfected 293T cell line by TNK2 polyclonal antibody. A: Non-transfected lysate. B: TNK2 transfected lysate. 7.5% SDS PAGEGTX107868 diluted at 1:500Print:Print
