Catalog Number | GTX108480 |
Product Name | B7-2 antibody |
Full Name | CD86 molecule |
Product Description | Rabbit polyclonal antibody to B7-2 (B7-2 molecule) |
Synonyms | B7-2 | B70 | CD28LG2 | LAB72 | MGC34413 |
Background | This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined. [provided by RefSeq] |
Clonality | Polyclonal |
Host | Rabbit |
Immunogen | Synthetic peptide contain a sequence corresponding to a region within amino acids 265 and 329 of Human B7-2 |
Antigen Species | Human |
Tested Applications | Dot Blot |
Application Note | Further validation in progress. |
Specificity | This antibody is specific to the peptide antigen from B7-2. |
Species Cross Reactivity | Human - Not yet tested in other species |
Positive Controls | Synthetic peptide: 1:8,000 |
Target | B7-2 |
Predicted Target Size(KDa) | 37.69 |
Cellular Localization | Membrane |
Form Supplied | Liquid |
Concentration | 0.14 mg/ml |
Purification | Purified by antigen-affinity chromatography. |
Storage Buffer | 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
Storage Instruction | Keep as concentrated solution. Aliquot and store at -20¨¬C or below. Avoid multiple freeze-thaw cycles. |
Notes | For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |