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Unit |
Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-24-345243 |
AM05264PU-N |
14-3-3 protein theta//Human, Mouse, Rat, Bovine/Mouse |
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Subject
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14-3-3 protein theta |
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Description
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/ Human, Mouse, Rat, Bovine/Mouse |
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Clonality
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Mono |
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Company
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Acris Antibodies GmbH |
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Application
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Enzyme Immunoassay, Western blot / Immunoblot |
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Conjugation
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Immunogen
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Contents
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Description: | Manufacturer | Acris Antibodies GmbH | | Quantity | 100 ug | | Reactivity | Human, Mouse, Rat, Bovine | | Presentation | Purified | | Applications | Enzyme Immunoassay, Western blot / Immunoblot | | Isotype | IgG1 | | Host | Mouse | | Clone | 3B9 | | PDF datasheet | view | | Shipping to | Worldwide | | Synonyms | 14-3-3 protein tau, 14-3-3 protein T-cell, YWHAQ, Protein HS1, FocusOn116 | | Swiss Prot Num | P27348 | | Product Type | Antibodies | |
| Immunogen | Swiss Prot Num: P27348 | | ? | Genename: YWHAQ | | Storage | Store the antibody at -20°C. Avoid repeated freezing and thawing. Shelf life: One year from despatch. | |
| Format | State: Liquid (sterile filtered) purified IgG fraction. | | ? | Purity: Purified | | ? | Buffer System: 20 mM Sodium Phosphate, pH 7.5, 150 mM Sodium Chloride, 50% Glycerol. | |
| Specificity | This antibody reacts specifically with the theta/tau isoform. | | Add. information | Molecular weight: 31 kDa | | Application | Suitable for use in Western Blot (1/5000). Positive controls: 3T3, PC12, Jurkat. | | Background | At least seven isoforms comprise the highly conserved 14-3-3 family of homo- and heterodimeric proteins that are abundantly expressed in all eukaryotic cells. Although more than seven isoforms of 14-3-3 have been described, some redundancies have appeared upon sequencing. The 14-3-3s are thought to be key regulators of signal transduction events mediated through their binding to serine-phosphorylated proteins. By interacting with Cdc25C, 14-3-3 regulates entry into the cell cycle and, through interaction with Bad, prevents apoptosis. Other proteins that have been shown to bind to 14-3-3s include members of the protein kinase C family, Cbl, IRS-1, polyoma middle-T antigen, nitrate reductase, S-raf and the IGF-1 receptor. Detection of 14-3-3 proteins in cerebrospinal fluid has been shown to be quite useful in the differential diagnosis of Creutzfeldt-Jakob disease and other prion diseases. | | Concentration | 1.0 mg/ml | | Focuson | 116 Antibody Panel to Proteins of the 14-3-3 family (14-3-3 beta, 14-3-3 gamma, 14-3-3 epsilon, 14-3-3 zeta, 14-3-3 theta, 14-3-3 sigma, 14-3-3 eta) | |
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