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Description |
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Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-320471 |
NB110-57241 |
200kDa Neurofilament Heavy Antibody (EP673Y)//Human, Mouse(-)/Rabbit |
1/EA |
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문의 |
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Subject
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200kDa Neurofilament Heavy Antibody (EP673Y) |
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Description
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/ Human, Mouse(-)/Rabbit |
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Clonality
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Mono |
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Company
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Novus biologicals |
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Application
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ICC, IHC-P, Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Rt, Mu(-), Hu | | Applications: | ICC, WB, IHC | | Clonality: | Monoclonal | | | Gene: | NEFH | | Purity: | protein A purified | | Host: | Rabbit | | | Specificity: | A synthetic peptide corresponding to residues in human NF-H was used as immunogen. | | Publications: | Antibody has not yet been mentioned in a publication. | Details: | Clone: | EP673Y | | Isotype: | IgG | | Immunogen: | Cytomegalovirus gB Envelpe Protein (pUL55, gp58/116, gC-1 and glycoprotein B) | Gene Symbol: NEFH | Entrez: | 4744 (Human) | | | 380684 (Mouse) | | | 24587 (Rat) | | Swiss Prot: | P12036 (Human) | | Related Genes: | NEFM, NEFL, NFASC, SOD1, PRPH, GFAP, LDLR, FH, CFH, MAP2, MAPT, IGFALS, NES, REN, PRNP, AGT, MBP, UCHL1, METAP2, ACHE, HOXA9, MT1M, MAPK1, VIM, CLDN6, IL6, PSEN1, GPR158, PSEN2, RSPO4, PKP1, CDK5, ATP2A2, GAP-43, RANGAP1, MAPK9, CA3, SLC17A5, TAC1, LIF | Background: Neuofilaments (NF) are members of the intermediate filament protein family also known as 10nm filaments. These neuron-specific filaments are the major constituents of the axonal cytoskeleton (1). NFs are composed of three major proteins; NF-H, NF-L and NF-M and the ratio of each protein changes during neuronal development. NF-H is the heavy molecular weight protein (200 kDa), NF-M the medium (160 kDa) and NF-L the light protein (68kDa) (2). Phosphorylation of the NF-H tail domain modulates neurofilament transport, dynamics and organization within the axon. Accumulation of the protein or mutations in NF-H is observed during the progression of numerous neurological diseases such as amyotrophic lateral sclerosis (3). Species: | Reactivity: | Reacts in human and rat. Does not react in mouse. Not tested in other species. | Applications: | Uses: | WB: 1:2,000 IHC: 1:500 ICC: 1:100-250 | | Dilutions: | immunohistochemistry , Western Blot , Immunocytochemistry | Packaging: | Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. | | Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. | | Preservative: | 0.01% Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | | | | |
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