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Description |
Unit |
Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-320478 |
NB110-57265 |
68kDa Neurofilament Light Antibody (EP675Y)//Human, Mouse,/Rabbit |
1/EA |
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문의 |
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Subject
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68kDa Neurofilament Light Antibody (EP675Y) |
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Description
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/ Human, Mouse,/Rabbit |
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Clonality
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Mono |
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Company
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Novus biologicals |
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Application
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FACS, IP, Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Rt, Mu, Hu | | Applications: | WB, IP, FACS | | Clonality: | Monoclonal | | | Gene: | NEFL | | Purity: | Tissue culture supernatant | | Host: | Rabbit | | | Specificity: | A synthetic peptide corresponding to residues near the C-term of human NF-L was used as immunogen. | | Publications: | Antibody has not yet been mentioned in a publication. | Details: | Clone: | EP675Y | | Isotype: | IgG | | Immunogen: | A synthetic peptide corresponding to residues near the C-term of human NF-L was used as immunogen | Gene Symbol: NEFL | Entrez: | 4747 (Human) | | | 18039 (Mouse) | | | 83613 (Rat) | | Swiss Prot: | P07197 (Human) | | Related Genes: | NEFM, NF-H, NFASC, GFAP, MPZ, VIM, SOD1, KIF1B, LAMC2, MAPT, PRPH, NEFH, PMP22, MAP2, GJB1, MAD2L1BP, MBP, IGFALS, NF200, METAP2, HSPB1, ENO2, GAP-43, MFN2, PXMP2, NES, GCLC, GCA, GMCL1, GMCL1L, MTMR2, SYP, NGF, PHLDA2, BDNF, GARS, CDK5, DLG3, DES, MBL2 | Background: Neuofilaments (NF) are members of the intermediate filament protein family also known as 10nm filaments. These neuron-specific filaments are the major constituents of the axonal cytoskeleton (1). NFs are composed of three major proteins; NF-H, NF-L and NF-M and the ratio of each protein changes during neuronal development. NF-H is the heavy molecular weight protein (200 kDa), NF-M the medium (160 kDa) and NF-L the light protein (68kDa) (2). NF-L self polymerizes and provides a scaffold for NFs to form via cross-bridging with NF-H or NF-M (3). NF-L aggregation has been linked to the pathogenesis of neurodegenerative disease, such as degradation of motor neurons (4). Species: | Reactivity: | Reacts in human, mouse, and rat. Not tested in other species. | Applications: | Uses: | This antibody is useful for This antibody is useful for FACS, immunoprecipitation and Western Blot. | | Dilutions: | flow cytometry / FACS analysis 1:70, immunoprecipitation 1:50, Western Blot 1:50,000, | Packaging: | Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. | | Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. | | Preservative: | 0.01% Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | | | | |
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