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Description |
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Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-24-345254 |
AM05341PU-N |
3-Nitrotyrosine// |
1/EA |
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문의 |
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Subject
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3-Nitrotyrosine |
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Description
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Clonality
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Mono |
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Company
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Acris Antibodies GmbH |
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Application
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Frozen sections, Western blot / Immunoblot |
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Conjugation
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Immunogen
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Contents
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Description: | Manufacturer | Acris Antibodies GmbH | | Quantity | 100 ug | | Presentation | Purified | | Applications | Frozen sections, Western blot / Immunoblot | | Isotype | IgG1 | | Host | Mouse | | Clone | 2A12 | | PDF datasheet | view | | Shipping to | Worldwide | | Immunogen | 3-Nitrotyrosine-KLH | | Product Type | Antibodies | | Storage | The antibody can be shipped at 2-8°C. Store (in aliquots) at -20°C only. Avoid repeated freezing and thawing. Shelf life: one year from despatch. | | References | 1. Knight-Lozano, C.A., et al. Cigarette smoke exposure and hypercholesterolemia incrase mitochondrial damage in cardiovascular tissues. Circulation, 105, 849 - 854 (2002). 2. Khan, F. & Siddiqui, A.A. Prevalence of anti-3-nitrotyrosine antibodies in the joint synovial fluid of patients with rheumatoid arthritis, osteoarthritis and systemic lupus erythematosus. Clin Chim Acta, 370, 100 - 107 (2006). 3. Deeb, R.S., et al. Tyrosine nitration in prostaglandin H2 synthase. J Lipid Res, 43, 1718 - 1726 (2002). 4. Blanchard-Fillion, B., et al. Metabolism of 3-nitrotyrosine induces apoptotic death in dopaminergic cells. J Neurosci, 26, 6124 - 6130 (2006). | |
| Format | State: Liquid purified Ig fraction. | | ? | Purity: Purified | | ? | Buffer System: 20 mM Sodium Phosphate, 150 mM Sodium Chloride, 50% Glycerol, 3mM Sodium Azide, pH 7.5 | |
| Specificity | This antibody detects 3-Nitrotyrosine. | | Application | Western Blot: 1/1000. Immunohistochemistry on Frozen Sections. | | Background | Protein tyrosine nitration results in a post-translational modification that is increasingly receiving attention as an important component of nitric oxidesignaling. While multiple nonenzymatic mechanisms are known to be capable of producing nitrated tyrosine residues, most tyrosine nitration events involve catalysis by metalloproteins such as myeloperoxidase, eosinophilperoxidase, myoglobin, the cytochrome P-450s, superoxide dismutase and prostacyclin synthase. Various studies have shown that protein tyrosinenitration is limited to specific proteins and that the process is selective. For example, exposure of human surfactant protein A (SP-A) to oxygen-nitrogen intermediates generated by activated alveolar macrophages resulted in specific nitration of SP-A at tyrosines 164 and 166, while addition of 1.2 mMCO 2 resulted in additional nitration at tyrosine 161. The presence of nitrotyrosine-containing proteins has shown high correlation to disease states such as atherosclerosis, Alzheimeru™s disease, Parkinsonu™s disease and amyotrophic lateral sclerosis.55 kD 160 kD. | | Concentration | 1.0 mg/ml | |
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