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Description |
Unit |
Price
(VAT별도) |
납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-24-345292 |
AP07163PU-N |
ABL1//Human, Mouse/Rabbit |
1/EA |
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문의 |
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Subject
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ABL1 |
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Description
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/ Human, Mouse/Rabbit |
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Clonality
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Mono |
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Company
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Acris Antibodies GmbH |
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Application
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Paraffin Sections |
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Conjugation
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Immunogen
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Contents
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Description: | Manufacturer | Acris Antibodies GmbH | | Quantity | 50 ug | | Reactivity | Human, Mouse | | Presentation | Aff - Purified | | Applications | Paraffin Sections | | Isotype | IgG | | Host | Rabbit | | PDF datasheet | view | | Shipping to | Not USA/Canada | | Synonyms | c-ABL, p150, JTK7 | | Swiss Prot Num | P00519 | | Immunogen | Synthetic peptide | | Product Type | Antibodies | | Storage | Store the antibody undiluted at -20°C for one month or (in aliquots) at -70°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. | |
| Format | State: Liquid purified Ig | | ? | Purification: Immunoaffinity Chromatography | | ? | Buffer System: PBS, 0.02% sodium azide, 50% glycerol | |
| Specificity | This antibody reacts to ABL1 amino acids surrounding Tyrosine 412. | | Application | Immunohistochemistry: 20?g/ml. | | Background | ABL1, an Abl type protein kinase, is associated with cell differentiation, cell division, cell adhesion and stress response. Kinase activity of nuclear ABL1 is mediated by retinoblastoma protein. Additionally, ABL1 has been shown to bind nuclear DNA, and this binding activity is regulated by CDC2-mediated phosphorylation. ABL1 (-/-) mice are osteoporotic and display increased perinatal mortality, reduced fertility, foreshortened crania and defects in the maturation of B cells in bone marrow. At least two mRNA isoforms have been reported, 6- or 7-kb, with alternatively spliced first exons joined to the common exons 2-11. Alterations of ABL1 by chromosomal rearrangement or viral transduction lead to malignant transformation. Further, a very long intron in the ABL1 gene is a target for translocations. Translocations of ABL1 to the breakpoint cluster region (BCR) on chromosome 22 lead to chronic myeloid leukemia and acute lymphocytic leukemia. | |
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