|
| |
| Cat. No |
Model |
Description |
Unit |
Price
(VAT별도) |
납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-24-345337 |
AP05119PU-N |
Activin receptor type 1 (ACRV1)//Chicken/Sheep |
1/EA |
|
|
|
 |
문의 |
|
|
|
|
|
|
|
Subject
|
Activin receptor type 1 (ACRV1) |
|
Description
|
/ Chicken/Sheep |
|
Clonality
|
Mono |
|
Company
|
Acris Antibodies GmbH |
|
Application
|
Paraffin Sections, Western blot / Immunoblot, Immunoprecipitation |
|
Conjugation
|
|
|
Immunogen
|
|
|
Contents
|
Description: | Manufacturer | Acris Antibodies GmbH | | Quantity | 250 ug | | Reactivity | Chicken | | Presentation | Purified | | Applications | Paraffin Sections, Western blot / Immunoblot, Immunoprecipitation | | Isotype | IgG | | Host | Sheep | | PDF datasheet | view | | Shipping to | Worldwide | | Synonyms | Activin receptor type IA, ACVRLK2, ALK2, SKR1, ACRV1A | | Swiss Prot Num | Q90ZK6 | | Immunogen | Recombinant protein derived from the extracellular domain of the chicken ALK2 protein. Protein shares significant homology with the mouse, rat and human sequences. | | Product Type | Antibodies | | Storage | The antibody can be shipped at ambient temperature. Store (in aliquots) at -20°C only. Avoid repeated freezing and thawing. Shelf life: one year from despatch. | | References | 1. Lai, Y.T., et al. Activin receptor-like kinase 2 can mediate atrioventricular cushion transformation. Dev. Biol. 2000, 222, 1 - 11. 2. Gu, Z., et al. The type I serine/threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryo. Development 1999, 126, 2551 - 2561. 3. Macias-Silva, M., et al. Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2. J. Biol. Chem. 1998, 273, 25628 - 25636 | |
| Format | State: Liquid purified Ig | | ? | Purity: Purified | | ? | Buffer System: Phosphate buffered saline with 0.08% sodium azide | |
| Specificity | This antibody reacts to ALK2. | | Application | Western Blot: 5 - 10 ?g/ml. Immunoprecipitation: 5 ?g/mg of protein lysate. Immunohistochemistry on paraffin sections: 5 - 10 ?g/ml. | | Background | Activin Receptor-Like Kinase 2 is a member of the superfamily of type I receptors for transforming growth factor-beta (TGF-beta). This receptor binds both activin and bone morphogenic proteins (BMPs). In mice, these receptors are expressed mainly in the extraembryonic visceral endoderm before gastrulation and later in both embryonic and extraembryonic cells during gastrulation. Also, it has been shown that ALK2 associates with and phosphorylates Smad1 and also regulated Smad5 and Smad8 phosphorylation. It also induces the Tlx2 promoter in the absense of BMP7. | | Concentration | 1,0 mg/ml | |
|
|
|
|
