| Synonyms | AB3648 |
| Immunogen | BALB/C mice were injected with adenovirus. |
| Product Type | Antibodies |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| References | i) Harlow et al. Mol cell Biol 6: 1579, 1986. ii) Harlow et al. J Virol 3: 533, 1985. iii) Klein et al. Science 238: 1539, 1987. |
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| Format | State: Liquid Ig fraction |
| ? | Buffer System: 10 mM citrate buffer, pH 6.0 - containing sodium azide as preservative. |
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| Specificity | This antibody reacts with adenovirus. Cellular Localization: Nuclear |
| Application | Immunohistochemistry on paraffin embedded sections: diluted of 1:50-1:75 in an ABC method (30 minutes at room temperature) Recommended Positive Control: Adenovirus infected tissue |
| Background | The adenovirus early gene products E1A is a potent stimulator of cellular proliferation, which when overexpressed can overcome the growth-inhibitory effects of TGF-beta. The E1A region encodes a series of related proteins (35-46 kD) with multifunctional capabilities and forms a specific complex with the retinoblastoma tumor suppressor gene product. The E1a and E1B regions together comprise the transforming region of adenovirus. While expression of E1A alone is sufficient to immortalize primary cells, complete transformation requires the additional expression of the E1B region. |
