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Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-24-345362 |
AP05253PU-N |
Adiponectin//Human, Mouse, Rat/Rabbit |
1/EA |
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문의 |
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Subject
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Adiponectin |
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Description
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/ Human, Mouse, Rat/Rabbit |
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Mono |
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Company
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Acris Antibodies GmbH |
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Application
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Frozen sections, Western blot / Immunoblot |
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Conjugation
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Immunogen
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Contents
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Description: | Manufacturer | Acris Antibodies GmbH | | Quantity | 100 ug | | Reactivity | Human, Mouse, Rat | | Presentation | Aff - Purified | | Applications | Frozen sections, Western blot / Immunoblot | | Isotype | IgG | | Host | Rabbit | | PDF datasheet | view | | Shipping to | Worldwide | | Synonyms | ADIPOQ, ACDC, ACRP30, APM1, GBP28 | | Swiss Prot Num | Q15848 | | Immunogen | A 15 amino acid peptide from near the amino terminus of human adiponectin | | Product Type | Antibodies | | Storage | Store the antibody (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C. Avoid repeated freezing and thawing. Shelf life: One year from despatch. | | References | 1) Fantuzzi G. Adipose tissue, adipokines, and inflammation. J. Allergy Clin. Immunol. 2005; 115:911-9. 2) Tsao T-S, Lodish HF, and Fruebis J. ACRP30, a new hormone controlling fat and glucose metabolism. Euro. J. Pharmacol. 2002; 440:213-21. 3.) Wong GW, Wang J, Hug C, et al. A family of Acrp30/ adiponectin structural and functional paralogs. Proc. Natl. Acad. Sci. USA 2004; 101:10302-7. 4) Shapiro L and Scherer PE. The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor. Curr. Biol. 1998; 8:335-8. 5) Lihn AS, Pedersen SB, and Richelsen B. Adiponectin: action, regulation and association to insulin sensitivity. Obes. Rev. 2005; 6:13-21. 6) UniProtKB/Swiss-Prot entry Q15848, http://au.expasy.org/uniprot/Q15848, Accessed February 27, 2007. | |
| Format | State: Liquid Ig fraction | | ? | Purity: Aff - Purified | | ? | Purification: Affinity chromatography | | ? | Buffer System: Phosphate buffered saline with 0.02 % sodium azide | |
| Specificity | This antibody detects Adiponectin. | | Application | Western Blot: 1 ?g/ml. Positive Control: Rat brain cell lysate. Immunohistochemistry. | | Background | Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines (reviewed in 1). One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-?-related proteins (CTRPs) 1-7 (2). Unlike the CTRPs, which are expressed in a wide variety of tissues, adiponectin is reported to be expressed exclusively by differentiated adipocytes (3). These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene (4). It is present in high levels in normal human plasma, but is reduced in obese subjects and often in those with increased insulin resistance and type 2 diabetes, suggesting that adiponectin may be a useful pharmacological target in various metabolic diseases (5). Adiponectin a secreted protein synthesized exclusively by adipocytes (6). | | Concentration | 0.5 mg/ml | |
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