Synonyms | Retinoblastoma-like Protein 1, PRB1, RBL1 |
Swiss Prot Num | P28749 |
Immunogen | GST fusion protein to the N terminus of p107. |
Product Type | Antibodies |
|
Immunogen | Swiss Prot Num: P28749 |
? | Genename: RBL1 |
Storage | Store the antibody at -20°C. Avoid repeated freezing and thawing. Shelf life: One year from despatch. |
|
Format | State: Liquid (sterile filtered) purified IgG fraction. |
? | Purity: Purified |
? | Purification: Protein A/G chromatography (> 95 % by SDS-PAGE). |
? | Buffer System: PBS containing 0.08% Sodium Azide as preservative. |
|
Specificity | KAB6 recognizes both the phosphorylated and unphosphorylated forms of p107 at a MW of 107 kDa. |
Application | Suitable for Western Blots at 1/1000. |
Background | P107 is related both in structure and function to the retinoblastoma tumor suppressor protein and p130 (collectively known as pocket proteins) and are known to regulate the activity of E2F transcription factors. E2F transcription factors regulate the expression of a number of genes important in cell proliferation, particularly those involved in the progression through G1 and into the S-phase of the cell cycle. Binding of p107 converts E2F transcription factors from transcriptional activators to transcriptional repressors. |