|
|
Cat. No |
Model |
Description |
Unit |
Price (VATº°µµ) |
³³±â |
Àç°í |
DataSheet |
ÁÖ¹®/°ßÀû |
LCA-24-359328 |
AP06261PU-N |
p15 Ink//Human, Mouse, Rat/Rabbit |
1/EA |
|
|
|
|
¹®ÀÇ |
|
|
|
|
|
|
Subject
|
p15 Ink |
Description
|
/ Human, Mouse, Rat/Rabbit |
Clonality
|
Mono |
Company
|
Acris Antibodies GmbH |
Application
|
Enzyme Immunoassay, Paraffin Sections, Western blot / Immunoblot |
Conjugation
|
|
Immunogen
|
|
Contents
|
Description: Manufacturer | Acris Antibodies GmbH | Quantity | 100 ug | Reactivity | Human, Mouse, Rat | Presentation | Aff - Purified | Applications | Enzyme Immunoassay, Paraffin Sections, Western blot / Immunoblot | Host | Rabbit | PDF datasheet | view | Shipping to | Worldwide | Product Type | Antibodies | Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: One year from despatch. | |
Format | State: Liquid purified Ig fraction (> 95% pure SDS-PAGE). | ? | Purification: Affinity Chromatography using epitope-specific immunogen | ? | Buffer System: Phosphate buffered saline (PBS), pH~7.2 containing 15 mM Sodium Azide as preservative. | |
Specificity | This antibody detects endogenous levels of p15 INK protein. | Application | ELISA: 1/5000~1/10000. Western Blot: 1/500~1/1000. Immunohistochemistry: 1/50-1/200 Immunofluorescence: 1/50~1/200. | Background | The normal progression of cells through the cell cycle is under the control of the cyclin dependent protein kinases Cdk4 and Cdk6 which are subject to inhibition by the mitotic inhibitory protein, p16. An isolated member of the p16 family has been designated p15. p15 expression is upregulated approximately 30-fold in TGF?©÷-treated human keratinocytes, suggesting that p15 may act as an effector of TGF?©÷-mediated cell cycle arrest. The gene encoding p15 has been mapped to chromosome 9p21 at a position adjacent to the p16 gene at a site of frequent chromosomal abnormality in human tumors. It has been suggested that p15 may function as an effector of TGF?©÷-mediated cell cycle arrest through inhibition of Cdk4 and Cdk6 kinases. | Concentration | 1,0 mg/ml | |
|
|
|
|