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Cat. No |
Model |
Description |
Unit |
Price (VATº°µµ) |
³³±â |
Àç°í |
DataSheet |
ÁÖ¹®/°ßÀû |
LCA-24-359332 |
AP06259PU-N |
p16//Human, Mouse/Rabbit |
1/EA |
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Subject
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p16 |
Description
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/ Human, Mouse/Rabbit |
Clonality
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Mono |
Company
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Acris Antibodies GmbH |
Application
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Enzyme Immunoassay, Western blot / Immunoblot |
Conjugation
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Immunogen
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Contents
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Description: Manufacturer | Acris Antibodies GmbH | Quantity | 100 ug | Reactivity | Human, Mouse | Presentation | Aff - Purified | Applications | Enzyme Immunoassay, Western blot / Immunoblot | Host | Rabbit | PDF datasheet | view | Shipping to | Worldwide | Product Type | Antibodies | Storage | Store the antibody undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch. | |
Format | State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE). | ? | Purification: Affinity Chromatography using epitope-specific immunogen. | ? | Buffer System: Phosphate buffered saline (PBS) with 15 mM Sodium Azide as preservative, approx. pH 7.2. | |
Specificity | This antibody detects endogenous levels of p12INK/p16INK4 protein. | Application | ELISA: 1/5000~1/20000. Western Blot: 1/500~1/1000. | Background | The melanoma susceptibility locus cyclin-dependent kinase inhibitor 2A encodes two unrelated cell growth inhibitors, p16 and alternative reading frame (ARF). It acts as a negative regulator of the proliferation of normal cells, a key barrier to tumor evelopment, by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.The p16 coding sequence is more often mutated in melanoma families than is the ARF sequence. | Concentration | 1,0 mg/ml | |
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