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Description |
Unit |
Price
(VAT별도) |
납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-24-354420 |
AP07739PU-N |
DAD1//Human, Mouse/Rabbit |
1/EA |
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문의 |
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Subject
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DAD1 |
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Description
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/ Human, Mouse/Rabbit |
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Clonality
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Mono |
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Company
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Acris Antibodies GmbH |
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Application
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Immunofluorescence, Paraffin Sections, Western blot / Immunoblot |
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Conjugation
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Immunogen
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Contents
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Description: | Manufacturer | Acris Antibodies GmbH | | Quantity | 50 ug | | Reactivity | Human, Mouse | | Presentation | Purified | | Applications | Immunofluorescence, Paraffin Sections, Western blot / Immunoblot | | Host | Rabbit | | PDF datasheet | view | | Shipping to | Not USA/Canada | | Synonyms | DAD-1, EC 2.4.1.119 | | Swiss Prot Num | P61803 | | Immunogen | Synthetic Peptide corresponding to 14 amino acids near the C-terminus of human DAD1. | | Product Type | Antibodies | | Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C to -70°C for longer. Dilute only prior to immediate use. Avoid repeated freezing and thawing. Shelf life: one year from despatch. | |
| Format | State: Liquid purified IgG fraction. | | ? | Purification: Ion Exchange Chromatography. | | ? | Buffer System: Phosphate Buffered Saline PBS containing 0.02% Sodium Azide as preservative. | |
| Specificity | Species Human and Mouse. | | Application | Immunohistochemistry on Paraffin Sections (2.5 ?g/ml). Immunocytochemitsry. Western Blot (0.5-2 ?g/ml). | | Background | Defender of cell death 1 (DAD1) was initially discovered in BHK21 cells as a negative regulator of programmed cell death, a process important for normal organism development and tissue homeostasis. DAD1 was later shown to be a subunit of the mammalian oligosaccharyl-transferase complex and is required for its function and structural integrity. Mice lacking DAD1 express abnormal N-linked glycoproteins and undergo increased apoptotic-associated embryonic death. Furthermore, overexpression of DAD1 mRNA is seen in some human hepatocellular carcinomas, indicating it may also play a role in carcinogenesis. It should be noted that DAD1 is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains. | |
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