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Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-321037 |
NB200-106PEP |
p19ARF// |
1/EA |
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p19ARF |
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Description
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Novus biologicals |
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Immunogen
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Contents
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Description: | Manufacturer | Novus Biologicals Inc. | | Quantity | 0.05 mg | | PDF datasheet | view | | Shipping to | Not USA/Canada | | Synonyms | ARF, CDK4 inhibitor P16 INK4, CDK4I, CDKN2, CDKN2A, Cell cycle negative regulator beta, CMM2, Cyclin dependent kinase 4 inhibitor A, Cyclin dependent kinase inhibitor 2A, Cyclin dependent kinase inhibitor P12, Cyclin dependent kinase inhibitor P16, INK4, INK4a ARF, Melanoma p16 inhibits CDK4, MLM, MTS1, Multiple tumor suppressor 1, P14, P16INK4a, P19, TP16 | | Product Type | Antibodies | | Storage | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. | | References | (NOTE: These references cite a previous lot of Novus Biologicals' NB 200-106) 1. Athena W. Lin & Scott W. Lowe Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation. PNAS. 98(9): 5025-5030, 2001. 2. Tournier, C. et al. Requirement of JNK for Stress-Induced Activation of the Cytochrome c-Mediated Death Pathway. Science. 288: 870-874, 2000. 3. Sharpless, N., et al. Loss of p16(Ink4a) with retention of p19ARF predisposes mice to tumorigenesis. PNAS. 98(9): 5025-5030, 2001. 4. Nambiar, P., et al. Role of the Alternative Reading Frame (P19)-p53 Pathway in an in Vivo Murine Colon Tumor Model. Cancer Research. 62(13): 3667-3674, 2002. 5. Tsai, K., et al. ARF mutation accelerates pitutary tumor development in Rb-/- mice. PNAS. 99(26):16865-16870, 2002. 6. Heron-Milhavet, L., et al. Insulin-like Growth Factor I Induces MDM2-dependent Degradation of p53 via the p38 MAPK Pathway in Response to DNA Damage. Journal of Biological Chemistry. 277(18):15600-15606, 2002. 7. Petrenko, O., et al. Macrophage Migration Inhibitory Factor Deficiency Is Associated with Altered Cell Growth and Reduced Susceptibility to Ras-mediated Transformation. Journal of Biological Chemistry. 278(13):11078-11085, 2003. 8. Lee, S., et al. Hepatitis B virus X Protein Differentially Regulates Cell Cycle Progression in X-transforming Versus Nontransforming Hepatocyte (AML12) Cell Lines. Journal of Biological Chemistry. 277(10):9730-8740,2002. 9. Unnikrishnan, I: Absence of p53 Complements Defects in Abelson Murine Leukemia Virus Signaling. Journal of Virolgy, June 2003,p. 6208-6215. 10. Melnikova, V., et al. Genomic alterations in spontaneous and carcinogen-induced murine melanoma cell lines. Oncogene. 23: 2347-2356, 2004. 11. Khan, S., et al. p14ARF is a component of the p53 response following ionizing irradiation of normal human fibroblasts. Oncogene. 23:6040-6046, 2004. 12. Sharpless, N., et al. The differential impact of p16INK4a or p19ARF deficiency on cell growth and tumorigenesis. Oncogene. 23:379-385, 2004. 13. Fehrenbacher, N., et al. Sensitization to the Lysosomal Cell Death Pathway upon Immortalization and Transformation. Cancer Research. 64: 5301-5310, 2004. 14. Baker, D., et al. BubR1 insufficiency causes early onset of aging -associate phenotypes and infertility in mice. Nature Genetics. 36: 744-749, 2004. 15. Yi, Y., et al. p19(ARF) Determines the Balance between Normal Cell Proliferation Rate and poptosis during Mammary Gland Development. Mol. Biol. Cell. 15: 2302-2311, 2004. 16. Matsumura, Y., et al. Resistance of CD1d-/-Mice to Ultraviolet-Induced Skin Cancer Is Associated with Increased Apoptosis. Am. J. Pathol. 165: 879-887, 2004. 17. Sachs, Z., et al. p16(Ink4a) Interferes with Abelson Virus Transformation by Enhancing Apoptosis. J. Virol. 78: 3304-3311, 2004. 18. Gong, L., et al. Active Akt and Functional p53 Modulate Apoptosis in Abelson Virus-Transformed Pre-B Cells. J. Virol. 78: 1636-1644, 2004. 19. Sun, L., et al. Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG. Genes & Dev. 18: 1035-1046, 2004. 20. Aslanian, A., et al. Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics. Genes & Dev. 18: 1413-1422, 2004. 21. Khan, S. H. et al. Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion. PNAS. 97(7):3266-3271, 2000. (Western Blot, Mouse) 22. Baker, D.J., et al. Early aging-associated pheotypes in Bub3/Rae1 haploinsufficient mice. J. Cell Biol. 172:529-540, 2006. 23. Klochendler-Yeivin, A., et al. Increased DNA damage sensitivity and apoptosis in cells lacking the Snf5/Ini1 subunit of the SWI/SNF chromatin remodeling complex. Mol. Cell. Biol. 26:2661-2674, 2006. | |
| Specificity | , This peptide is specific for NB200-106 only. | | Add. information | Research Areas: Cancer, Lipid and Metabolism | | Application | , Used as a blocking peptide for NB 200-106. | | Background | The INK4a/ARF locus encodes two unrelated tumor suppressor proteins, p16INK4a and p19ARF. These proteins restrain cell growth by modifying the functions of the retinoblastoma protein and p53, respectively. INK4a/ARF is among the most frequently mutated t | | Concentration | 1 mg/ml | |
| Format | Buffer System: No Preservative | |
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