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Description |
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Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-354551 |
NB110-53818C |
ATG5 Antibody [DyLight 649]//Bovine, Human/Rabbit |
1/EA |
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문의 |
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Subject
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ATG5 Antibody [DyLight 649] |
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Description
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/ Bovine, Human/Rabbit |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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IHC-P, Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Ze, Xp, Mk, Po, Bv, Rt, Mu, Hu | | Applications: | WB, IHC | | Clonality: | Polyclonal | | | Gene: | ATG5 | | Purity: | peptide affinity purified | | Host: | Rabbit | | | Specificity: | This is selective for the full-length and calpain cleaved isoform proteins. The short isoform is missing a.a. 1-79. The calpain cleaved form of ATG5 is missing a.a. 195-275. | | Publications: | Antibody has been mentioned in at least 3 publications. | Details: | Conjugate: | DyLight 649 | | Immunogen: | A synthetic peptide made to an N-terminal region (within residues 1-50) of the human ATG5 protein. [Swiss-Prot# Q9H1Y0] | | Localization: | Cytoplasm. Co-localizes with non-muscle actin. | Gene Symbol: ATG5 | Entrez: | 9474 (Human) | | | 365601 (Rat) | | Swiss Prot: | Q9H1Y0 (Human) | | Related Genes: | ATG12, BECN1, ATG7, MAP1LC3A, MTOR, BCL2, GABARAPL2, GABARAPL1, BAX, TP53, ATG10, BCL2L1, ULK1, CASP3, PIK3CG, HSPA5, ATG3, SH3GLB1, BAK1, ATG16L1, DDX58, RFC2, RFC1, ATP6V0A1, RFC4, CDKN2A, BNIP3, HTT, FAS, CDKN1A, UVRAG, CTSB, HSPA4, EXOSC10, AKT1, SQSTM1, CYCS, IL24, BCHE, JUN | Background: Autophagy is an important mechanism for nonselective intracellular breakdown whereby cytosol and organelles are encapsulated in vesicles, which are then engulfed and digested by lytic vacuoles/lysosomes. ATG5 is required for autophagy. It conjugates to ATG12 and associates with isolation membrane to form autophagosomes. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed. Conjugation to ATG12 is essential for autophagy, but is not required for association with isolation membrane. ATG5 also plays an important role in the apoptotic process. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Species: | Reactivity: | Reacts with human, mouse, rat, cow, pig, primate, Xenopus and Zebrafish. | Applications: | Uses: | This antibody is useful for Western blot analysis. The molecular weight of human ATG5 is ~33 kDa. | | Dilutions: | immunohistochemistry 2.5ug/ml, Western Blot 1:500 | | Concentrations: | 1.0 mg/ml | | Conjugated Ab's: | 4 conjugated antibodies | Packaging: | Buffer: | 50mM sodium borate | | Storage: | Store at 4C. Do not freeze. | | Preservative: | No Preservative | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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