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| Cat. No |
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Description |
Unit |
Price
(VAT별도) |
납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-322071 |
NB100-1482 |
15-PGDH Antibody//Human/Goat |
1/EA |
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문의 |
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Subject
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15-PGDH Antibody |
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Description
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/ Human/Goat |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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PEP-ELISA, Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Hu | | Applications: | WB, PEP-ELISA | | Clonality: | Polyclonal | | | Gene: | HPGD | | Purity: | Immunogen affinity purified | | Host: | Goat | | | Specificity: | Prostaglandin dehydrogenase 1 | | Publications: | Antibody has not yet been mentioned in a publication. | Details: | Isotype: | IgG | | Immunogen: | Synthetic peptide C-DYDTTPFQAKTQ, representing the C-Terminus of the human protein (residues 255-266), according to NP_000851. | Gene Symbol: HPGD | Entrez: | 3248 (Human) | | Swiss Prot: | NP_000851. (Human) | | Related Genes: | PTGS2, PHGDH, PTGES, PGD, F2, PTGR1, MAPK1, COX5A, COX8A, PGF, H6PD, EPHB2, PGR, JUN, CRH, G6PD, FASN, SLCO2A1, IL10, PTGS1, CREB1, PLEKHM1, BCHE, CELA3B, ETS1, FOS, EGFR, ENOPH1, MMP9, NR3C1, KRT20, TNF, ME3, FABP4, ALOX5, ME1, ME2, PPARG, NTRK1, POMC | Background: Prostaglandins are involved in many physiologic and cellular processes, such as inflammation. The NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH, type I) is the main enzyme of prostaglandin degradation. By catalyzing the conversion of the 15-hydroxyl group of prostaglandins into a keto group, this ubiquitous enzyme strongly reduces the biologic activity of these molecules. The induction of 15-PGDH expression by dexamethasone and other glucocorticoids at the therapeutic level provides an additional biochemical mechanism for the anti-inflammatory action of these glucocorticoids. Species: | Reactivity: | Human and chimpanzee. | Applications: | Uses: | This antibody is useful for Peptide ELISA and Western Blot. Experiments gave bands at approx 26kDa and 50kDa in Human Duodenum lysates after 0.1?g/ml antibody staining. These bands correspond to earlier findings in literature with different antibodies (PMID: 11889207). This protein has a calculated MW of 29.0kDa according to NP_000851. | | Dilutions: | Peptide ELISA 1:128000, Western Blot 0.1-1?g/ml | | Concentrations: | 0.5 mg/ml | | Positive Controls: | 1 positive controls | Packaging: | Buffer: | Tris-saline containing 0.02% Na azide [pH7.3] with 0.5% BSA | | Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. | | Preservative: | 0.02% Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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