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Description |
Unit |
Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-24-347006 |
AP07132PU-N |
APC / DP2.5//Human, Mouse, Rat, Bovine, Sheep/Rabbit |
1/EA |
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문의 |
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Subject
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APC / DP2.5 |
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Description
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/ Human, Mouse, Rat, Bovine, Sheep/Rabbit |
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Clonality
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Mono |
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Company
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Acris Antibodies GmbH |
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Application
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Paraffin Sections |
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Conjugation
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Immunogen
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Contents
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Description: | Manufacturer | Acris Antibodies GmbH | | Quantity | 50 ug | | Reactivity | Human, Mouse, Rat, Bovine, Sheep | | Presentation | Aff - Purified | | Applications | Paraffin Sections | | Host | Rabbit | | PDF datasheet | view | | Shipping to | Not USA/Canada | | Synonyms | Adenomatous polyposis coli protein | | Swiss Prot Num | P25054 | | Immunogen | Synthetic peptide from the C-terminus of human APC | | Product Type | Antibodies | | Storage | Store the antibody at 2 - 8 °C. DO NOT FREEZE! Shelf life: one year from despatch. | |
| Format | State: Liquid Ig fraction | | ? | Purification: Immunoaffinity chromatography | | ? | Buffer System: PBS, pH 7.4, 0.2% BSA, 0.05% sodium azide | |
| Specificity | This antibody detects Adenomatous Polyposis Coli Protein (APC) at C-term. | | Application | Immunohistochemistry on paraffin sections (10 ?g/ml). Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100°C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature. | | Background | Although the metabolic function of the tumor suppressor APC gene is not known, it is involved in maintaining cytoplasmic levels of the Wingless (Wg)/Wnt effector (Armadillo)/beta-catenin at a steady state. During development, beta-catenin is involved in cell growth and axis patterning. APC binds beta-catenin preventing it to act as a transcription factor and targets it for destruction. Mutations in the APC gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy such as Gardner syndrome and colorectal cancer. | | Concentration | 0.2 mg/ml | |
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