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Description |
Unit |
Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-354807 |
NBP1-19368 |
B MyB Antibody//Human, Mouse,/Rabbit |
1/EA |
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문의 |
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Subject
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B MyB Antibody |
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Description
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/ Human, Mouse,/Rabbit |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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IF, Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Rt, Mu, Hu | | Applications: | IF, WB | | Clonality: | Polyclonal | | | Gene: | MYBL2 | | Purity: | Affinity purified | | Host: | Rabbit | | | Specificity: | B-Myb (G573/577) detects endogenous levels of B-Myb protein. | Details: Gene Symbol: MYBL2 | Entrez: | 4605 (Human) | | | 17865 (Mouse) | | | 296344 (Rat) | | Related Genes: | MYB, MYBL1, CCNA2, RBL1, CDK2, RBL2, CDKN1A, E2F1, MYC, CCND1, ARID4A, E2F4, RAB3GAP1, NOLC1, CDC2, POLD1, CLU, LIN9, TP53, CDK4, PCNA, RB1, CDKN2A, JUN, TCEAL1, CCNB1, SP1, D4S234E, BCL2, E2F3, NOL3, DAND5, PSG1, ZNF217, MORF4L1, MORF4, PARP1, PAK3, SLC12A9, AURKA | Background: Expression of the B-Myb transcription factor is upregulated during late G1 phase of the cell cycle by an E2F-dependent transcriptional mechanism. B-Myb is specifically phosphorylated during S phase, suggesting that a cyclin-dependent kinase (Cdk) regulates its activity. Consistent with this notion, the S phase-specific cyclin A/Cdk2 was found previously to enhance B-Myb transactivation activity in cotransfected cells. There is evidence that B-Myb is a direct physiological target for cyclin A/Cdk2. Data indicate that phosphorylation by cyclin A/Cdk2 is directly involved in enhancing B-Myb transactivation activity and that levels of endogenous cyclin A/Cdk2 activity may contribute to cell line-specific B-Myb function . Nuclear entry of B-Myb is dependent on multiple nuclear localization signals (NLS's). Mutagenesis of the putative NLS's of B-Myb has identified two separate NLS's, NLS1 and NLS2. Each of the two NLS's is essential for efficient nuclear targeting. Species: | Reactivity: | Human, Mouse, Rat | Applications: | Uses: | This antibody is useful for Western Blot and Immunofluorescence.Western blot analysis of B-Myb (G573/577) antibody in extracts from K562 cells. | | Dilutions: | Western Blot 1:500-1:1000,immunofluorescence 1:50-1:200, | Packaging: | Buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2. | | Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. | | Preservative: | No Preservative | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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