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Description |
Unit |
Price
(VAT별도) |
납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-354812 |
NB100-92146 |
B Raf Antibody//Human, Mouse,/Rabbit |
1/EA |
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문의 |
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Subject
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B Raf Antibody |
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Description
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/ Human, Mouse,/Rabbit |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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ELISA, IHC-P |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Rt, Mu, Hu | | Applications: | IHC, ELISA | | Clonality: | Polyclonal | | | Gene: | BRAF | | Purity: | Immunogen affinity purified | | Host: | Rabbit | | | Specificity: | B-Raf (F594) detects endogenous levels of B-Raf protein. | Details: Gene Symbol: BRAF | Entrez: | 673 (Human) | | | 114486 (Rat) | | Related Genes: | RAF1, MAPK1, ZHX2, EPHB2, KRAS, CDKN2A, HRAS, MAPK3, TP53, EGFR, NRAS, MAP2K1, MLH1, SNRPE, PIK3CG, PIK3CA, AKT1, RET, MAP2K2, PTEN, CTNNB1, MAPK12, ARAF, RAP1A, CDKN1A, MSH2, TERF2IP, APC, EGF, CCND1, ERBB2, PROC, CDK4, PIK3CB, PIK3CD, RASSF1, MGMT, TCEAL1, D4S234E, PKA | Background: Several serine/threonine protein kinases have been implicated as intermediates in signal transduction pathways. These include ERK/MAP kinases, ribosomal S6 kinase (Rsk) and Raf-1. Raf-1 is a cytoplasmic protein with intrinsic serine/threonine activity. It is broadly expressed in nearly all cell lines tested to date and is the cellular homolog of v-Raf, the product of the transforming gene of the 3611 strain of murine sarcoma virus. The unregulated kinase activity of the v-Raf protein has been associated with transformation and mitogenesis while the activity of Raf-1 is normally suppressed by a regulatory N-terminal domain. Raf-A, a second member of the Raf gene family of serine/threonine protein kinases, exhibits substantial homology to Raf-1 within the kinase domain of the two molecules, but less homology elsewhere. Expression of Raf-B is highly restricted with highest levels in the cerebrum and testis. Species: | Reactivity: | This antibody is reactive against Human, Mouse, Rat. | Applications: | Uses: | Immunohistochemistry analysis of B-Raf (F594) antibody in paraffin-embedded human breast carcinoma tissue. | | Dilutions: | ELISA 1:1000-1:5000, immunohistochemistry 1:50-1:200, | | Concentrations: | 1.0 mg/ml | | Positive Controls: | 1 positive controls | Packaging: | Buffer: | Phosphate buffered saline, pH 7.2. | | Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. | | Preservative: | 15mM Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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