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Subject
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B Raf [phospho Thr439] Antibody |
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Description
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/ Human/Rabbit |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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DB, ELISA |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Protein Type: | Peptide | | Species: | Hu | | Applications: | DB, ELISA | | Clonality: | Polyclonal | | | Gene: | BRAF | | Purity: | Whole antisera | | Host: | Rabbit | | | Specificity: | BRAF - v-raf murine sarcoma viral oncogene homolog B1 [Thr439] | Details: | Modification: | phospho Thr439 | | Isotype: | IgG | | Immunogen: | Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding T439 of human BRAF. | Gene Symbol: BRAF | Entrez: | 673 (Human) | | Omim: | 164757 (Human) | | Swiss Prot: | NP_004324; P15056 (Human) | | Related Genes: | RAF1, MAPK1, ZHX2, EPHB2, KRAS, CDKN2A, HRAS, MAPK3, TP53, EGFR, NRAS, MAP2K1, MLH1, SNRPE, PIK3CG, PIK3CA, AKT1, RET, MAP2K2, PTEN, CTNNB1, MAPK12, ARAF, RAP1A, CDKN1A, MSH2, TERF2IP, APC, EGF, CCND1, ERBB2, PROC, CDK4, PIK3CB, PIK3CD, RASSF1, MGMT, TCEAL1, D4S234E, PKA | Background: This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq] Species: | Reactivity: | Human. Other species not tested. | Applications: | Uses: | This antibody is useful for ELISA, Dot Blot (peptide). | | Dilutions: | ELISA,Dot Blot | Packaging: | Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. | | Preservative: | 0.09% Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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