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Description |
Unit |
Price
(VAT별도) |
납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-348011 |
NB100-1726 |
53BP1 Antibody//Human, Mouse/Rabbit |
1/EA |
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문의 |
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Subject
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53BP1 Antibody |
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Description
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/ Human, Mouse/Rabbit |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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IHC-P |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Mu, Hu | | Applications: | IHC | | Clonality: | Polyclonal | | | Gene: | TP53BP1 | | Purity: | Affinity purified | | Host: | Rabbit | | Details: | Immunogen: | The epitope recognized by this antibody maps to a region between residue 350 and 400 of human tumor protein p53 binding protein 1 using the numbering given in entry NP_005648.1 (GeneID 7158). | Gene Symbol: TP53BP1 | Entrez: | 7158 (Human) | | Swiss Prot: | NP_005648.1 (Human) | | Related Genes: | H2AFX, ATM, TP53, MDC1, NBN, BRCA1, ATR, MMAB, ANTXR1, MRE11A, CHEK2, NLRP2, CDKN1A, CHEK1, TERF2, ARTN, RAD9A, RAD51, CRB2, JUN, E2F1, PRKDC, RAD50, TCEAL1, NFKB1, D4S234E, RB1, RNF8, FOS, DCLRE1C, DDR1, TP53BP2, BLM, UBE2N, TBPL1, CDKN2A, HEPACAM, PAXIP1, MDM2, IFI16 | Background: P53-binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes to the presumptive sites of damage, specifically, double-strand breaks. This also suggests a role in DNA repair, maintaining genomic stability. Species: | Reactivity: | Human and Mouse. | Applications: | Uses: | This antibody is useful for immunohistochemistry. No other applications have been tested. Suggested working dilution: * Immunohistochemistry: 1:100-1:500 (FFPE sections) Epitope exposure is not recommended (citrate buffer may hinder staining). Likely to work with frozen sections. *The investigator should determine the optimal working dilution for a specific application. | | Dilutions: | immunohistochemistry 1:100-1:500, | Packaging: | Buffer: | Tris-buffered Saline containing 0.1% BSA | | Storage: | Store at 4C. Do not freeze. | | Preservative: | 0.09% Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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