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Description |
Unit |
Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-348015 |
NBP1-02868 |
53BP1 Antibody//Human/Rabbit |
1/EA |
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문의 |
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Subject
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53BP1 Antibody |
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Description
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/ Human/Rabbit |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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IHC-P, Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Hu | | Applications: | IHC-P, WB | | Clonality: | Polyclonal | | | Gene: | TP53BP1 | | Purity: | Affinity purified | | Host: | Rabbit | | | Specificity: | Synthetic peptide corresponding to the carboxy-terminus of h53BP1, conjugated to a carrier protein. | | Publications: | Antibody has been mentioned in at least 1 publication. | Details: | Immunogen: | the carboxy-terminus of h53BP1, conjugated to a carrier protein | Gene Symbol: TP53BP1 | Entrez: | 7158 (Human) | | Swiss Prot: | Q12888 (Human) | | Related Genes: | H2AFX, ATM, TP53, MDC1, NBN, BRCA1, ATR, MMAB, ANTXR1, MRE11A, CHEK2, NLRP2, CDKN1A, CHEK1, TERF2, ARTN, RAD9A, RAD51, CRB2, JUN, E2F1, PRKDC, RAD50, TCEAL1, NFKB1, D4S234E, RB1, RNF8, FOS, DCLRE1C, DDR1, TP53BP2, BLM, UBE2N, TBPL1, CDKN2A, HEPACAM, PAXIP1, MDM2, IFI16 | Background: P53-binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes to the presumptive sites of damage, specifically, double-strand breaks. This also suggests a role in DNA repair, maintaining genomic stability.Tumor protein p53 binding protein 1 binds to the central domain of p53 required for site-specific DNA binding thus inhibiting the ability of p53 to bind DNA. TP53BP1 also functions as a checkpoint protein with properties of a DNA double-strand break sensor. It is a putative substrate of ATM kinase and is phosphorylated in response to DNA damage and localizes to sites of double-strand breaks. Species: | Reactivity: | This antibody is reactive to Human. | Applications: | Uses: | This antibody is useful for the following applications and at the following dilutions: Western Blot, Immunohistochemistry-Paraffin 5 ug/ml | | Dilutions: | Western Blot,Immunohistochemistry-Paraffin 5 ug/ml, | Packaging: | Buffer: | PBS | | Storage: | Store at 4C short term. Aliquot and store at -80C long term. Avoid freeze-thaw cycles. | | Preservative: | No Preservative | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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