Synonyms | Disheveled-associated activator of morphogenesis 1;DAAM1;KIAA0666 |
Swiss Prot Num | Q9Y4D1 |
Immunogen | This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human DAAM1. |
Product Type | Antibodies |
Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
References | 1. Liu,W., Proc. Natl. Acad. Sci. U.S.A. 105 (1), 210-215 (2008) 2. Yamashita,M.,Genes Cells 12 (11), 1255-1265 (2007) 3. Lu,J., J. Mol. Biol. 369 (5), 1258-1269 (2007) |
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Format | State: Liquid purified Ig fraction. |
? | Purification: Protein A Chromatography followed by peptide affinity purification. |
? | Buffer System: PBS with 0.09% (W/V) Sodium Azide as preservative. |
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Specificity | This antibody detects DAAM1 (C-term). |
Add. information | Molecular weight: 123473 Da |
Application | ELISA: 1/1,000. Western Blot: 1/50-1/100. Immunohistochemistry: 1/10-1/50. |
Background | Functions of the cell cortex, including motility, adhesion, and cytokinesis, are mediated by the reorganization of the actin cytoskeleton and recent evidence suggests a role for the Formin homology (FH) proteins in these processes. DAAM1 contains FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. Wnt/Fz signaling activates the small GTPase Rho, a key regulator of cytoskeleton architecture, to control cell polarity and movement during development. Activation requires Dvl-Rho complex formation, an assembly mediated by DAAM1, which is thought to function as a scaffolding protein. |
Caution | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Concentration | 0.25 mg/ml |