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Description |
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Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-348327 |
NB110-57609 |
alpha Tubulin 4a Antibody (EP1332Y)//Human, Mouse,/Rabbit |
1/EA |
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문의 |
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Subject
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alpha Tubulin 4a Antibody (EP1332Y) |
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Description
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/ Human, Mouse,/Rabbit |
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Clonality
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Mono |
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Company
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Novus biologicals |
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Application
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FACS, ICC, IHC-P, IP, Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Rt, Mu, Hu | | Applications: | ICC, WB, IP, IHC, FACS | | Clonality: | Monoclonal | | | Gene: | TUBA4A | | Purity: | Ascites | | Host: | Rabbit | | | Specificity: | A synthetic peptide corresponding to residues near the N-term of human | | Publications: | Antibody has been mentioned in at least 1 publication. | Details: | Clone: | EP1332Y | | Isotype: | IgG | | Immunogen: | Synthetic peptide: HGIQPDGQMPSDKT, corresponding to N terminal amino acids 28-41 of Human alpha TubulinBLAST 'HGIQPDGQMPSDKT' | Gene Symbol: TUBA4A | Entrez: | 7277 (Human) | | | 22143 (Mouse) | | | 500929 (Rat) | | Swiss Prot: | P68363 (Human) | | Related Genes: | GAPDH, B2M, BDNF, TBP, RUNX1, VCL, PGK1, RABGAP1L, SERPINB4, SERPINB3, PPIA, PRDX1, S100A9, SOD2, HPRT1, EZR, TUBA1A, EPB41L3, TPM1, H2, PF4V1, E11, MASCOT, SLC24A3, STXBP1, EEF1A1, PSMD1, MYC, PRM1, TUFM, SGCA, RHCG, ARNTL, SEPT3, DNASE1, ITGB3, TUBA3C, CSTB, PHB, RPLP1 | Background: Microtubules are essential parts in eukaryotic cell structures, transportation, and mitosis. It consists mainly of 2 soluble protein subunits, alpha and beta tubulin. Beta tubulin binds to alpha tubulin to form tubulin heterodimer which is post-translationally modified (1). The tubulin dimer complex binds to GTP and assembles onto the positive ends of microtubules. After incorporation into the microtubules, bound GTP is hydrolyzed by beta tubulin. The stability of the dimer in the microtubules is depended on presence of beta tubulin, where dimer with GTP bound beta-tubulin is stable to microtubule incorporation (2). For both type of tubulin, the carboxy-terminal tail is pos-translationally modified to regulate associated protein binding at microtubule surface (3). A mutation on alpha tubulin has been linked to abnormal neuronal migration and neurodevelopmental disorders in human (4). Species: | Reactivity: | Reacts in human, mouse, and rat. Not tested in other species. | Applications: | Uses: | WB: 1:50,000 IHC: 1:250 | | Dilutions: | flow cytometry / FACS analysis , immunohistochemistry , immunoprecipitation , Western Blot , Immunocytochemistry | | Positive Controls: | 1 positive controls | Packaging: | Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.18 M NaCl, 40% Glycerol, 0.25 mM EDTA, 25 mM Citric Acid, and 0.5% BS | | Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. | | Preservative: | 0.25% Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | | | | |
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