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Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-24-366867 |
AP05564SU-N |
14-3-3 protein beta/alpha//Human, Mouse, Rat, Bovine, Rabbit, Sheep/Rabbit |
1/EA |
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Subject
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14-3-3 protein beta/alpha |
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Description
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/ Human, Mouse, Rat, Bovine, Rabbit, Sheep/Rabbit |
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Clonality
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Mono |
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Company
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Acris Antibodies GmbH |
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Application
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Enzyme Immunoassay, Western blot / Immunoblot |
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Conjugation
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Immunogen
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Contents
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Description: | Manufacturer | Acris Antibodies GmbH | | Quantity | 0.1 ml | | Reactivity | Human, Mouse, Rat, Bovine, Rabbit, Sheep | | Presentation | Serum | | Applications | Enzyme Immunoassay, Western blot / Immunoblot | | Isotype | IgG | | Host | Rabbit | | PDF datasheet | view | | Shipping to | Worldwide | | Synonyms | YWHAB, KCIP-1, Protein 1054, FocusOn116 | | Swiss Prot Num | P31946 | | Immunogen | Synthetic peptide corresponding to acetylated N-terminal sequence of sheep 14-3-3 beta | | Product Type | Antibodies | | Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. | | References | 1. Martin, H. et al. (1993) Antibodies against major brain isoforms of 1433 protein. An antibody specific for the Nacetylated aminoterminus of a protein. FEBS 331: 296 - 303. 2. Aitken, A. et al. (2006) 1433 proteins: A historic overview. Seminars in Cancer Biology 16: 162 - 172. | |
| Format | State: Liquid serum containing 0.09% Sodium Azide (NaN3) | |
| Specificity | This antibody recognises the acetylated N-terminal of 14-3-3 beta. It is a member of the 14-3-3 family which consists of 30 kDa proteins that are involved in multiple protein kinase signalling pathways, regulation of cell cycle progression, cytoskeletal structure, transcription, intracellular trafficking and targeting. Protein interactions with 14-3-3 show distinct preference for its different isoforms and are regulated by phosphorylation of both 14-3-3 and the bound protein. 14-3-3 beta plays a role in the pathogenesis of systemic lupus erythematosus and is involved in negative regulation of p90 ribosomal S6 kinase activity and tuberous sclerosis tumour suppressor proteins. It also binds IGF1 receptor, RAF1 and CDC25 phosphatases. This antibody may not react with recombinant proteins that are not Nacetylated. | | Application | Immunohistochemistry on paraffin sections. ELISA. Western Blot: detects a band of approximately 30kDa in HEK293 cell lysates. | | Caution | (A full Health and Safety assessment is available upon request) This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only. | | Focuson | 116 Antibody Panel to Proteins of the 14-3-3 family (14-3-3 beta, 14-3-3 gamma, 14-3-3 epsilon, 14-3-3 zeta, 14-3-3 theta, 14-3-3 sigma, 14-3-3 eta) | |
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