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Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-24-366874 |
AP05565SU-N |
14-3-3 protein epsilon//Human, Mouse, Rat, Bovine, Chicken, Rabbit, Sheep/Rabbit |
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Subject
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14-3-3 protein epsilon |
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Description
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/ Human, Mouse, Rat, Bovine, Chicken, Rabbit, Sheep/Rabbit |
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Clonality
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Mono |
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Company
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Acris Antibodies GmbH |
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Application
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Enzyme Immunoassay, Paraffin Sections, Western blot / Immunoblot |
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Conjugation
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Immunogen
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Contents
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Description: | Manufacturer | Acris Antibodies GmbH | | Quantity | 0.1 ml | | Reactivity | Human, Mouse, Rat, Bovine, Chicken, Rabbit, Sheep | | Presentation | Serum | | Applications | Enzyme Immunoassay, Paraffin Sections, Western blot / Immunoblot | | Isotype | IgG | | Host | Rabbit | | PDF datasheet | view | | Shipping to | Worldwide | | Synonyms | 14-3-3E, YWHAE, FocusOn116 | | Swiss Prot Num | P62258 | | Immunogen | Synthetic corresponding to C-terminal sequence of sheep 14-3-3 epsilon. | | Product Type | Antibodies | | Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. | | References | 1. Jones, H. et al. (1995) Expression and Structural Analysis of 1433 Proteins. J. Mol. Biol. 245: 375 - 384. 2. Aitken, A. et al. (2006) 1433 proteins: A historic overview. Seminars in Cancer Biology 16: 162 - 172. | |
| Format | State: Liquid serum containing 0.09% Sodium Azide (NaN3) | |
| Specificity | This antibody recognises a C-terminal epitope of 14-3-3 epsilon. | | Application | Immunohistochemistry on paraffin sections. ELISA. Western Blot: detects a band of approximately 30kDa in HEK293 cell lysates. | | Background | 14-3-3 is a member of the 14-3-3 family which consists of 30 kDa proteins that are involved in multiple protein kinase signalling pathways, regulation of cell cycle progression, cytoskeletal structure, transcription, intracellular trafficking and targeting. Protein interactions with 14-3-3 show distinct preference for its different isotypes and are regulated by phosphorylation of both 14-3-3 and the bound protein. 14-3-3 epsilon is expressed in all mammals. It is deleted in small cell lung cancers disrupting the G(2) checkpoint. During apoptosis, cleavage of 14-3-3 protein by caspase-3 increases the affinity between bad and Bcl-x(L). When bound by ERK, 14-3-3 epsilon is thought to deactivate heat shock factor 1 in cells recovering from heat shock. It is also a potential suicide susceptibility gene. | | Caution | (A full Health and Safety assessment is available upon request) This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only. | | Focuson | 116 Antibody Panel to Proteins of the 14-3-3 family (14-3-3 beta, 14-3-3 gamma, 14-3-3 epsilon, 14-3-3 zeta, 14-3-3 theta, 14-3-3 sigma, 14-3-3 eta) | |
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