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Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-24-366875 |
AP05568SU-N |
14-3-3 protein epsilon//Human, Mouse, Rat, Bovine, Chicken, Rabbit, Sheep/Rabbit |
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Subject
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14-3-3 protein epsilon |
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Description
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/ Human, Mouse, Rat, Bovine, Chicken, Rabbit, Sheep/Rabbit |
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Clonality
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Mono |
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Company
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Acris Antibodies GmbH |
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Application
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Enzyme Immunoassay, Paraffin Sections, Western blot / Immunoblot |
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Conjugation
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Immunogen
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Contents
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Description: | Manufacturer | Acris Antibodies GmbH | | Quantity | 0.1 ml | | Reactivity | Human, Mouse, Rat, Bovine, Chicken, Rabbit, Sheep | | Presentation | Serum | | Applications | Enzyme Immunoassay, Paraffin Sections, Western blot / Immunoblot | | Isotype | IgG | | Host | Rabbit | | PDF datasheet | view | | Shipping to | Worldwide | | Synonyms | 14-3-3E, YWHAE, FocusOn116 | | Swiss Prot Num | P62258 | | Immunogen | Synthetic peptide corresponding to acetylated N-terminal sequence of sheep 14-3-3 epsilon | | Product Type | Antibodies | | Storage | Store the antibody undiluted at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf life: one year from despatch. | | References | 1. Martin, H. et al. (1993) Antibodies against the major brain isoforms of 14-3-3 protein. An antibody specific for the N-acetylated amino-terminus of a protein. FEBS 331: 296-303. 2. Aitken, A. et al. (2006) 14-3-3 proteins: A historic overview. Seminars in Cancer Biology 16: 162-172. | |
| Format | State: Liquid serum | | ? | Buffer System: 0.09% Sodium Azide (NaN3) | |
| Specificity | This antibody recognises the acetylated N-terminal of 14-3-3 epsilon. The antibody may not react with recombinant proteins that are not N-acetylated. | | Application | Immunohistochemistry on paraffin sections (requires antigen retrieval using heat treatment prior to staining of paraffin sections). ELISA. Western blot. Histology Positive Control Tissue: Normal brain tissue. | | Background | 14-3-3 epsilon is a member of the 14-3-3 family which consists of 30 kDa proteins that are involved in multiple protein kinase signalling pathways, regulation of cell cycle progression, cytoskeletal structure, transcription, intracellular trafficking and targeting. Protein interactions with 14-3-3 show distinct preference for its different isoforms and are regulated by phosphorylation of both 14-3-3 and the bound protein. 14-3-3 epsilon is expressed in all mammals. It is deleted in small cell lung cancers disrupting the G(2) checkpoint. During apoptosis, cleavage of 14-3-3 protein by caspase-3 increases the affinity between bad and Bcl-x(L). When bound by ERK, 14-3-3 epsilon is thought to deactivate heat shock factor 1 in cells recovering from heat shock. It is also a potential suicide susceptibility gene. | | Focuson | 116 Antibody Panel to Proteins of the 14-3-3 family (14-3-3 beta, 14-3-3 gamma, 14-3-3 epsilon, 14-3-3 zeta, 14-3-3 theta, 14-3-3 sigma, 14-3-3 eta) | |
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