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Price
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재고 |
DataSheet |
주문/견적 |
| LCA-24-366897 |
AP05572SU-N |
14-3-3 protein zeta/delta//Human, Mouse, Rat, Bovine, Chicken, Sheep/Rabbit |
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Subject
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14-3-3 protein zeta/delta |
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Description
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/ Human, Mouse, Rat, Bovine, Chicken, Sheep/Rabbit |
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Clonality
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Mono |
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Company
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Acris Antibodies GmbH |
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Application
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Enzyme Immunoassay, Western blot / Immunoblot |
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Conjugation
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Immunogen
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Contents
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Description: | Manufacturer | Acris Antibodies GmbH | | Quantity | 0.1 ml | | Reactivity | Human, Mouse, Rat, Bovine, Chicken, Sheep | | Presentation | Serum | | Applications | Enzyme Immunoassay, Western blot / Immunoblot | | Isotype | IgG | | Host | Rabbit | | PDF datasheet | view | | Shipping to | Worldwide | | Synonyms | YWHAZ, KCIP-1, FocusOn116 | | Swiss Prot Num | P29361 | | Immunogen | Synthetic peptide corresponding to acetylated N-terminal sequence of sheep 14-3-3 zeta. | | Product Type | Antibodies | | Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. | | References | 1. Martin, H. et al. (1993) Antibodies against major brain isoforms of 14-3-3 protein. An antibody specific for the Nacetylated aminoterminus of a protein. FEBS 331: 296 - 303. 2. Aitken, A. et al. (2006) 14-3-3 proteins: A historic overview. Seminars in Cancer Biology 16: 162 - 172. | |
| Format | State: Liquid serum containing 0.09% Sodium Azide (NaN3) | |
| Specificity | This antibody recognizes the acetylated N-terminal of 14-3-3 zeta in all mammals. This antibody may not react with recombinant proteins that are not N-acetylated. | | Application | Immunohistochemistry on paraffin sections: requires antigen retrieval using heat treatment prior to staining of paraffin sections. ELISA. Western Blot: detects a band of approximately 30kDa in HEK293 cell lysates. | | Background | It is a member of the 14-3-3 family which consists of 30kDa proteins that are involved in multiple protein kinase signaling pathways, regulation of cell cycle progression, cytoskeletal structure, transcription, intracellular trafficking and targeting. Protein interactions with 14-3-3 show distinct preference for its different isotypes and are regulated by phosphorylation of both 14-3-3 and the bound protein. 14-3-3 zeta is a susceptibility gene for paranoid schizophrenia and is overexpressed in the temporal cortex of cognitively impared Alzheimers patients. The protein binds yeast Sps1/Ste20-related kinase 1 (YSK1) and localizes to the golgi, possibly linking YSK1 signaling, protein transport, cell adhesion and migration. It co-localizes with epidermal growth factor receptor to the plasma membrane following epidermal growth factor signaling. The zeta isoform is involved in MAPKAPK2-mediated phosphorylation which may have a role in p38 MAPK-dependent inflammation. When bound to ADAM 22, 14-3-3 zeta is involved in cell adhesion. 14-3-3 zeta also interacts with cofilin, LIM-domain-containing protein kinase 1, protein kinase B/Akt and GPI alpha. | | Caution | (A full Health and Safety assessment is available upon request) This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only. | | Focuson | 116 Antibody Panel to Proteins of the 14-3-3 family (14-3-3 beta, 14-3-3 gamma, 14-3-3 epsilon, 14-3-3 zeta, 14-3-3 theta, 14-3-3 sigma, 14-3-3 eta) | |
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