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Description |
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Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-24-366911 |
AP05641SU-N |
4-HYDROXYNONENAL// |
1/EA |
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문의 |
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Subject
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4-HYDROXYNONENAL |
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Description
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Clonality
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Mono |
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Company
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Acris Antibodies GmbH |
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Application
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Enzyme Immunoassay, Western blot / Immunoblot |
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Conjugation
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Immunogen
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Contents
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Description: | Manufacturer | Acris Antibodies GmbH | | Quantity | 0.1 ml | | Presentation | Serum | | Applications | Enzyme Immunoassay, Western blot / Immunoblot | | Isotype | IgG | | Host | Goat | | PDF datasheet | view | | Shipping to | Worldwide | | Immunogen | 4-hydroxynonenal conjugate | | Product Type | Antibodies | | Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. | | References | 1. Boon, P. et al. (1999) Glutathione Conjugation of 4Hydroxytrans2,3nonenal in the Rat in Vivo, the Isolated Perfused Liver and Erythrocytes. Toxicol. Appl. Pharmacol. 159:214 - 23. 2. Dwivedi S, et al. (2007) Role of 4hydroxynonenal and its metabolites in signaling. Redox. Rep. 12:4 - 10. | |
| Format | State: Liquid serum containing 0.09% Sodium Azide (NaN3) | |
| Specificity | This antibody recognises 4-hydroxynonenal (HNE). | | Application | ELISA: 1:10000. Western Blot: 1:3000. | | Background | 4-hydroxynonenal is a 65 kDa, highly reactive aldehyde released upon oxidation of omega-6-insaturated fatty acids, often by free radicals. HNE acts to spread and increase the initial effects of free radical events. It binds nucleic acids, phospholipids and sulfhydryl, histidine and lysine groups. These conjugates cause the cytotoxic effects (including cell death) that occur during oxidative stress due to hydrogen peroxide, superoxide, UV, heat and oxidant chemicals. HNE plays a role in the pathogenesis of diseases, stimulating fibrogenesis and inflammation. It is thought to act as a sensor of external stimuli, inducing the stress response by modulating membrane receptors such as Epidermal growth factor receptor or Fas. It is thought that constitutive levels of HNE may be needed for normal cell functions as decreased HNE levels are associated with cell proliferation and increased HNE levels with elevated apoptosis. | | Caution | (A full Health and Safety assessment is available upon request) This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only. | |
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