|
| |
| Cat. No |
Model |
Description |
Unit |
Price
(VAT별도) |
납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-24-372287 |
AP01741PU-N |
E2F1 Transcription Factor//Human, Mouse/Rabbit |
1/EA |
|
|
|
 |
문의 |
|
|
|
|
|
|
|
Subject
|
E2F1 Transcription Factor |
|
Description
|
/ Human, Mouse/Rabbit |
|
Clonality
|
Mono |
|
Company
|
Acris Antibodies GmbH |
|
Application
|
Enzyme Immunoassay, Western blot / Immunoblot |
|
Conjugation
|
|
|
Immunogen
|
|
|
Contents
|
Description: | Manufacturer | Acris Antibodies GmbH | | Quantity | 100 ug | | Reactivity | Human, Mouse | | Presentation | Aff - Purified | | Applications | Enzyme Immunoassay, Western blot / Immunoblot | | Host | Rabbit | | PDF datasheet | view | | Shipping to | Worldwide | | Synonyms | E2F-1, RBBP3, RBBP-3, PBR3, RBAP-1, RBAP1, FocusOn059 | | Swiss Prot Num | Q01094 | | Product Type | Antibodies | | Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: One year from despatch. | |
| Format | State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE). | | ? | Purification: Affinity Chromatography using epitope-specific immunogen. | | ? | Buffer System: Phosphate buffered saline (PBS), pH~7.2 containing 15 mM Sodium Azide as preservative. | |
| Specificity | This antibody detects endogenous levels of E2F1 pThr433 protein. | | Application | ELISA: 1/5000-1/10000. Western Blot: 1/500-1/1000. | | Background | The human retinoblastoma gene product plays an important role in the negative regulation of cell proliferation. Functional inactivation of Rb can be mediated either through mutation or as a consequence of interaction with DNA tumor virus encoded proteins. Of all the Rb associations described to date, the identification of a complex between Rb and the transcription factor E2F most directly implicates Rb in regulation of cell proliferation. E2F was originally identified through its role in transcriptional activation of the Adenovirus E2 promoter. Sequences that are homologous to the E2F binding site exist upstream of a number of genes that encode proteins with putative functions in the G1/S phases of the cell cycle. E2F-1 is a member of a broader family of transcription regulators including E2F-2, E2F-3, E2F-4, E2F-5 and E2F-6, each of which forms heterodimers with a second protein, DP-1, forming an uœactiveu? E2F transcriptional regulatory complex. | | Concentration | 1.0 mg/ml | | Focuson | 059 Antibodies to E2F Transcription Factor Family | |
|
|
|
|
