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Cat. No |
Model |
Description |
Unit |
Price (VATº°µµ) |
³³±â |
Àç°í |
DataSheet |
ÁÖ¹®/°ßÀû |
LCA-24-364280 |
AP01654PU-N |
p21//Human, Mouse, Rat/Rabbit |
1/EA |
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¹®ÀÇ |
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Subject
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p21 |
Description
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/ Human, Mouse, Rat/Rabbit |
Clonality
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Mono |
Company
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Acris Antibodies GmbH |
Application
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Enzyme Immunoassay, Paraffin Sections, Western blot / Immunoblot |
Conjugation
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Immunogen
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Contents
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Description: Manufacturer | Acris Antibodies GmbH | Quantity | 100 ug | Reactivity | Human, Mouse, Rat | Presentation | Aff - Purified | Applications | Enzyme Immunoassay, Paraffin Sections, Western blot / Immunoblot | Host | Rabbit | PDF datasheet | view | Shipping to | Worldwide | Synonyms | Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1 | Swiss Prot Num | P38936 | Product Type | Antibodies | Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: One year from despatch. | |
Format | State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE). | ? | Purification: Affinity Chromatography using epitope-specific immunogen. | ? | Buffer System: Phosphate buffered saline (PBS), pH~7.2 containing 15 mM Sodium Azide as preservative. | |
Specificity | This antibody detects endogenous levels of p21Cip1 pThr145 protein. | Application | ELISA: 1/10000-1/20000. Western Blot: 1/500-1/1000. Immunohistochemistry: 1/50-1/200. | Background | The p53-inducible gene product, p21(WAF1/CIP1), plays a critical role in regulating the rate of tumor incidence. p21 is a kinase inhibitor that was originally identified as a cyclin-dependent kinase and PCNA-binding protein ble to inhibit Cdk catalytic activity and as a gene whose expression was induced by the tumor suppressor protein p53. p21 contributes to the regulation of cell division, mediation of negative growth signals, differentiation and senescence, modulation of the apoptotic response and activaion of certain cyclin-Cdks in response to mitogenic signals. Serine 146 is a phosphorylation site within the carboxy terminal regulatory domain of p21 and when modified in vivo influences p21-PCNA interactions. | Concentration | 1.0 mg/ml | |
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