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Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-355435 |
NBP1-00084C |
Beclin 1 Antibody (1B7) [DyLight 649]//Bovine, Chicken/Mouse |
1/EA |
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Subject
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Beclin 1 Antibody (1B7) [DyLight 649] |
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Description
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/ Bovine, Chicken/Mouse |
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Clonality
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Mono |
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Company
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Novus biologicals |
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Application
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IHC-P, Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Eq, Rt, Mk, Po, Mu, Hu, Ch, Bv | | Applications: | IHC-P, WB | | Clonality: | Monoclonal | | | Gene: | BECN1 | | Purity: | IgG purified | | Host: | Mouse | | | Specificity: | Beclin 1 (1B7) | | Publications: | Antibody has not yet been mentioned in a publication. | Details: | Conjugate: | DyLight 649 | | Clone: | 1B7 | | Immunogen: | Full length human Beclin 1 protein [Swiss-Prot# Q14457] | | Localization: | Cell Membrane, Cytoplasmic and Golgi Apparatus. Expressed in dendrites and cell bodies of cerebellar Purkinje cells. | Gene Symbol: BECN1 | Entrez: | 8678 (Human) | | Related Genes: | PIK3CG, BCL2, MAP1LC3A, ATG5, BCL2L1, MTOR, AKT1, UVRAG, PIK3C3, ATG7, CASP3, BAX, PIK3CA, PIK3CB, PIK3CD, SH3GLB1, MAPK8, TP53, DNAH5, ULK1, MAPK1, PCBD1, DNAI1, BID, PIK3R4, PTK2B, PARP1, HSPA5, PI3, EPHB2, HTT, NFKB1, RFC2, RFC1, ATP6V0A1, RFC4, PTEN, CYCS, CASP9, CASP8 | Background: Beclin 1 is the first identified mammalian gene to mediate autophagy and also has tumor suppressor and antiviral function. Autophagy, a process of bulk protein degradation through an autophagosomic-lysosomal pathway, is important for differentiation, survival during nutrient deprivation, and normal growth control, and is often defective in tumor cells. Beclin 1 was originally isolated in a yeast two hybrid screen to identify Bcl-2-binding partners and maps to a tumor susceptibility locus on human chromosome 17q21 that is frequently monoallelically deleted in human breast, ovarian and prostate cancer. Beclin 1 encodes an evolutionarily conserved 60 kDa coiled coil protein that is expressed in human muscle, epithelial cells and neurons. In gene transfer studies, beclin 1 promotes nutrient deprivation-induced autophagy, inhibits mammary tumorigenesis, and inhibits viral replication. Expression of the Beclin 1 protein is frequently decreased in malignant breast epithelial cells. Based upon these observations, it is speculated that beclin 1 may work through induction of autophagy to negatively regulate tumorigenesis and to control viral infections. Beclin 1 may also play a role in other biological processes in which autophagy is important such as cell differentiation and nutritional stress responses. Species: | Reactivity: | Reacts with human, mouse, rat, monkey, bovine, porcine, horse and chicken. 99% sequence identity with monkey, 98% identity with mouse and bovine, 97% identity with porcine, rat and horse, 91% identity with chicken. | Applications: | Uses: | This antibody is useful for Western blot, where a band is seen ~52 kDa. This antibody is also useful for immunohistochemistry-Paraffin. | | Dilutions: | Western Blot 2.0 ug/ml, Immunohistochemistry-Paraffin 1:50- 1:100 | | Concentrations: | 1.0 mg/ml | | Conjugated Ab's: | 4 conjugated antibodies | Packaging: | Buffer: | 50mM sodium borate | | Storage: | Store at 4C. Do not freeze. | | Preservative: | No Preservative | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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