| Synonyms | Multidrug resistance-associated protein 7, SIMRP7 |
| Swiss Prot Num | Q5T3U5 |
| Product Type | Antibodies |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
|
| Format | State: Liquid purified Ig |
| ? | Purification: Affinity chromatography |
| ? | Buffer System: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2. |
|
| Specificity | MRP7 antibody detects endogenous levels of MRP7 protein. |
| Application | ELISA: 1:40000~1:60000. WB: 1:500~1:1000. |
| Background | The MRP family is represented by nine similar ABC transporters that have the ability to transport structurally diverse lipophilic anions and operate as chemical efflux pumps. MRP7 (multidrug resistance-associated protein 7, ATPbinding cassette sub-family C member 10) is a multi-pass membrane protein that belongs to the ABC transporter family (conjugate transporter subfamily). MRP7 is involved with the ATP-dependent transport of 17?²-estradiol-D-17-?²-glucuronide (E217?²G). MRP7 is also probably involved in cellular detoxification through its lipophilic anion extrusion capabilities. MRP7 contains two ABC transmembrane type 1 domains and two ABC transporter domains. MRP7 likely has three isoforms. Isoform 2 is the most widely expressed, while isoform 1 is predominately expressed in the spleen. |
| Concentration | 1,0 mg/ml |
