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Description |
Unit |
Price
(VAT별도) |
납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-24-367001 |
AP12554PU-N |
ABL1//Human/Rabbit |
1/EA |
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문의 |
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Subject
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ABL1 |
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Description
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/ Human/Rabbit |
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Clonality
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Mono |
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Company
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Acris Antibodies GmbH |
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Application
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Enzyme Immunoassay, Paraffin Sections |
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Conjugation
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Immunogen
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Contents
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Description: | Manufacturer | Acris Antibodies GmbH | | Quantity | 0.1 mg | | Reactivity | Human | | Presentation | Aff - Purified | | Applications | Enzyme Immunoassay, Paraffin Sections | | Isotype | Ig | | Host | Rabbit | | PDF datasheet | view | | Shipping to | Worldwide | | Synonyms | c-ABL, p150, JTK7 | | Swiss Prot Num | P00519 | | Immunogen | This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y276 of human ABL1. | | Product Type | Antibodies | | Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. | | References | 1. Barnes, K., et al., Oncogene 24(20):3257-3267 (2005). 2. Kim, Y.R., et al., Genes Chromosomes Cancer 43(1):37-44 (2005). 3. Aichberger, K.J., et al., Blood 105(8):3303-3311 (2005). 4. Wei, G., et al., J. Biol. Chem. 280(13):12271-12278 (2005). 5. Robinson, H.M., et al., Leukemia 19(4):564-571 (2005). | |
| Format | State: Liquid purified Ig fraction. | | ? | Purification: Protein G Affinity Chromatography. Then, the antibody fraction is peptide affinity purified in a 2-step procedure with control and phosphorylated peptides. The phospho-specific antibody is eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. | | ? | Buffer System: PBS with 0.09% (W/V) Sodium Azide as preservative. | |
| Specificity | This antibody detects ABL1 pTyr276. Predicted to cross react with Mouse (100% Antigen Homology). | | Add. information | Molecular weight: 122873 Da | | Application | ELISA: 1/1,000. Dot Blot: 1/500. Immunohistochemistry: 1/50-1/100. | | Background | ABL1 is a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. | | Caution | This product is for research use only. Not for use in diagnostic or therapeutic procedures. | | Concentration | 0.25 mg/ml | |
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