| Synonyms | c-ABL, p150, JTK7 |
| Swiss Prot Num | P00519 |
| Immunogen | This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T754 of human ABL. |
| Product Type | Antibodies |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| References | 1. Saglio, G., et al., Cell. Mol. Life Sci. 61(23):2897-2911 (2004). 2. Deming, P.B., et al., Mol. Cell. Biol. 24(23):10289-10299 (2004). 3. Graux, C., et al., Nat. Genet. 36(10):1084-1089 (2004). 4. Monma, F., et al., Int. J. Hematol. 80(2):155-158 (2004). 5. Gustafson, W.C., et al., J. Biol. Chem. 279(10):9400-9408 (2004). |
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| Format | State: Liquid purified Ig fraction. |
| ? | Purification: Protein A Chromatography followed by two-step phosphospecific peptide affinity purification. |
| ? | Buffer System: PBS with 0.09% (W/V) Sodium Azide as preservative. |
|
| Specificity | This antibody detects ABL pThr754. |
| Add. information | Molecular weight: 122873 Da |
| Application | ELISA: 1/1,000. Dot Blot: 1/500. |
| Background | ABL1 is a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. |
| Caution | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Concentration | 0.25 mg/ml |
