| Synonyms | Angiotensin-converting enzyme 2 |
| Swiss Prot Num | Q9BYF1 |
| Immunogen | Synthetic peptide corresponding to a sequence within the amino terminus of human ACE2. |
| Product Type | Antibodies |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
|
| Format | State: Liquid purified Ig |
| ? | Purification: Affinity chromatography |
| ? | Buffer System: PBS containing 0.02% Sodium Azide |
|
| Specificity | This antibody is specific for Angiotensin-converting enzyme 2 (ACE2). |
| Application | Western Blot. Immunohistochemistry on paraffin sections. |
| Background | ACE2 is a carboxypeptidase which is expressed in a range of tissues including heart, kidney, testis and the gastrointestinal system. ACE2 is a homologue of ACE (Angiotensin-converting enzyme 1), although it has a distinct catalytic activity. ACE2 catalyzes the cleavage of active angiotensin II into angiotensin 1-7, which may counteract the effects of ACE by increasing vasodilatation. A recent discovery is that ACE2 serves as the cellular entry point for the severe acute respiratory syndrome (SARS) virus, functioning as a receptor for the SARS Spike protein. |
| Caution | (A full Health and Safety assessment is available upon request) This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
| Concentration | 1.0 mg/ml |
