Swiss Prot Num | P28749 |
Immunogen | Synthetic peptide corresponding to C-terminal of human p107 protein. |
Product Type | Antibodies |
Storage | Store the antibody undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch. |
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Format | State: Liquid purified Ig |
? | Buffer System: 10mM PBS, pH 7.4 with BSA and Sodium Azide |
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Specificity | This antibody reacts to P107. |
Application | Western Blot: 2 µg/ml. |
Background | The Rb (retinoblastoma) gene family is composed of three members: the RB gene (one of the best-studied tumor suppressor genes) and two related genes, p107 and pRb2/p130. The RB/p105 and p107 genes of the retinoblastoma family are tumor suppressor genes (TSGs) whose proteins are inactivated by interaction with T-antigen proteins encoded by polyomaviruses (e.g., simian virus 40 and human JC virus), which have been found to be highly tumorigenic in animals. The three Rb gene proteins share many structural and functional features and play a fundamental role in growth control. Very minimal genetic alterations in the p107 gene have been detected in human hematological malignancies. |
Concentration | 0,2 mg/ml |