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Cat. No |
Model |
Description |
Unit |
Price (VATº°µµ) |
³³±â |
Àç°í |
DataSheet |
ÁÖ¹®/°ßÀû |
LCA-24-375218 |
AP15702PU-S |
p18//Human, Mouse, Rat/Rabbit |
1/EA |
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¹®ÀÇ |
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Subject
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p18 |
Description
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/ Human, Mouse, Rat/Rabbit |
Clonality
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Mono |
Company
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Acris Antibodies GmbH |
Application
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Western blot / Immunoblot |
Conjugation
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Immunogen
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Contents
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Description: Manufacturer | Acris Antibodies GmbH | Quantity | 0.1 ml | Reactivity | Human, Mouse, Rat | Presentation | Purified | Applications | Western blot / Immunoblot | Host | Rabbit | PDF datasheet | view | Shipping to | Worldwide | Swiss Prot Num | P42773 | Immunogen | Synthetic peptide corresponding to C-terminal of mouse p18 | Product Type | Antibodies | Storage | Store the antibody (undiluted) at 2 – 8 °C. Shelf life: One year from despatch. | |
Format | State: Liquid affinity purified Ig fraction | ? | Buffer System: 10 mM PBS, pH 7.4 with BSA and Sodium Azide | |
Specificity | This antibody detects p18 at C-term. | Add. information | Molecular weight: 18kDa Cellular localisation: Nuclear | Application | Western blot: 1-2 µg/ml for 2 hrs at RT. Positive control: NIH3T3 cells. Colon carcinoma. | Background | The normal progression of cells through the cell cycle is under the control of the cyclin dependent protein kinases Cdk4 and Cdk6 which are subject to inhibition by the mitotic inhibitory protein p16. Isolated members of the p16 family have been designated p15 and p18, respectively. The p16 related protein, p18, interacts strongly with Cdk6 and, to a lesser extent, with Cdk4, but lacks apparent interaction with other Cdks. Recombinant p18 has been shown to inhibit cyclin D-Cdk6 kinase activity. In contrast to p21/p27 that form ternary complexes with cyclin-Cdks, only binary complexes of p15, p16 and p18 have been identified in association with Cdk4 and/or Cdk6. | Concentration | 0.2 mg/ml | |
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