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Description |
Unit |
Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-24-367174 |
AP01617PU-N |
I Kappa B alpha (IKBa)//Human, Mouse, Rat/Rabbit |
1/EA |
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문의 |
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Subject
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I Kappa B alpha (IKBa) |
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Description
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/ Human, Mouse, Rat/Rabbit |
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Clonality
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Mono |
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Company
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Acris Antibodies GmbH |
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Application
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Enzyme Immunoassay, Paraffin Sections, Western blot / Immunoblot |
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Conjugation
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Immunogen
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Contents
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Description: | Manufacturer | Acris Antibodies GmbH | | Quantity | 100 ug | | Reactivity | Human, Mouse, Rat | | Presentation | Aff - Purified | | Applications | Enzyme Immunoassay, Paraffin Sections, Western blot / Immunoblot | | Host | Rabbit | | PDF datasheet | view | | Shipping to | Worldwide | | Synonyms | NFKBIA, IKBA, MAD3, NFKBI, NF-kappa-B inhibitor alpha, I-kappa-B-alpha, IkappaBalpha, IkB-alpha | | Swiss Prot Num | P25963 | | Product Type | Antibodies | | Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: One year from despatch. | |
| Format | State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE). | | ? | Purification: Affinity Chromatography using epitope-specific immunogen. | | ? | Buffer System: Phosphate buffered saline (PBS), pH~7.2 containing 15 mM Sodium Azide as preservative. | |
| Specificity | This antibody detects endogenous levels of IkB-alpha pSer32/36 protein. | | Application | ELISA: 1/10000-1/20000. Western Blot: 1/500-1/1000. Immunohistochemistry: 1/50-1/200. | | Background | On the basis of both functional and structural considerations, members of the I?ºB family of proteins can be divided into four groups. The first of these groups, I?ºB-?± (a 35-37 kDa protein), includes the avian protein pp40 and the mammalian MAD-3, both of which inhibit binding of p50-p65 NF?ºB complex or Rel protein to their cognate binding sites but do not inhibit the binding of p50 homodimer to ?ºB sites, suggesting that the I?ºB-?± family binds to the p65 subunit of p50-p65 heterocomplex through Ankyrin repeats. The second member of the I?ºB family is represented by a 45 kDa protein designated I?ºB-?². The third group of I?ºB proteins is represented by I?ºB-?³, a 70 kDa protein identical in sequence with the C-terminal domain of the p110 precursor of NF?ºB p50 and expressed predominantly in lymphoid cells. An additional I?ºB family member has been identified as I?ºB-u, a 45 kDa protein which has several phosphorylated forms and is primarily found complexed with RelA and/or c-Rel. | | Concentration | 1.0 mg/ml | |
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