Synonyms | Alpha-1-microglobulin, HCP, Inter-alpha-trypsin inhibitor light chain, ITI-LC, ITIL, Bikunin, HI-30, EDC1, Trypstatin |
Swiss Prot Num | P02760 |
Immunogen | Highly pure human alpha-1-microglobulin, prepared from the urine of patients with chronic renal proteinuria (Molecular Weight 25-30 kD). |
Product Type | Antibodies |
Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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Format | State: Liquid purified Ig fraction. |
? | Purity: Purified IgG prepared by affinity chromatography on Protein G |
? | Purification: Affinity Chromatography on Protein G. |
? | Buffer System: PBS containing 0.09% Sodium Azide as preservative. |
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Specificity | This antibody recognises human alpha-1-Microglobulin. No cross-reactivity is observed with Urine Albumin, Retinol binding protein or beta-2-Microglobulin. It does Not react with Rat. |
Application | ELISA (1/500-1/1000). Immunodiffusion. |
Background | Alpha(1)microglobulin/bikunin precursor specifically interacts with the ORF3 protein of hepatitis E virus and has a direct role in enhancing alpha(1)microglobulin export from the hepatocyte. Bikunin has a role in downregulating PI3 kinase and suppressing tumor invasiveness and metastasis in ovaran cancer cells. I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (H1, H2 or H3) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2 and bikunin, inter-alpha-like inhibitor (I-alpha-LI) of H2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin. Interacts with FN1 |
Concentration | 5.0 mg/ml |