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| Cat. No |
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Description |
Unit |
Price
(VAT별도) |
납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-351006 |
NB400-117B |
ABCG8 Antibody [Biotin]//Human, Mouse/Rabbit |
1/EA |
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문의 |
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Subject
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ABCG8 Antibody [Biotin] |
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Description
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/ Human, Mouse/Rabbit |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Mu, Hu | | Applications: | WB | | Clonality: | Polyclonal | | | Gene: | ABCG8 | | Purity: | peptide affinity purified | | Host: | Rabbit | | | Specificity: | NB400-117 is specific for human ABCG8. | Details: | Conjugate: | Biotin | | Immunogen: | A synthetic peptide from the n-terminal region of human ABCG8 protein. | | Localization: | Integral membrane protein; multi-pass membrane protein. | Gene Symbol: ABCG8 | Entrez: | 64241 (Human) | | Swiss Prot: | Q9H221 (Human) | | Related Genes: | ABCG5, ABCA1, NPC1L1, ABCB4, LXR, ABCB11, CYP7A1, BAT5, BAT4, ABCG1, SCARB1, ABCC1, LDLR, NR1H4, ABCC2, ABCC3, ABCG2, NR0B2, SOAT2, KLHL1, PPARA, APOB, SLC10A1, NR1H3, VLDL, MSH3, INS, MTTP, MDM4, APOA1, RFC2, RFC1, ABCA4, ATP6V0A1, RFC4, MARCKSL1, CYP27A1, GPR177, SREBF2, SREBF1 | Background: ATP-binding cassette (ABC) transporter genes are involved in the regulation of the amount of dietary cholesterol retained in the body. ABCG8, expressed at high levels in the liver and intestine, normally cooperates with ABCG5 to limit intestinal absorption and promote biliary excretion of sterols. The mutated form of this transporter can lead to sterol accumulation and atherosclerosis or sitosterolemia, a rare autosomal recessive disorder, characterized by hyperabsorption of sterols and the inability to excrete sterols into bile. Species: | Reactivity: | Human and mouse. | Applications: | Uses: | This antibody is useful for Western Blot where a doublet is seen at ~67kDa and ~72kDa. Longer exposure times are needed to visualize the wild type ABCG8. For mouse, 100 ug protein (B6/129AKRFVB liver homogenate) loaded with antibody diluted at 1:500. | | Dilutions: | Western Blot 1:250 | | Concentrations: | 1.0 mg/ml | | Conjugated Ab's: | 4 conjugated antibodies | Packaging: | Buffer: | PBS | | Storage: | Store at 4C. Do not freeze. | | Preservative: | No Preservative | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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