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Description |
Unit |
Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-351080 |
NBP1-20094 |
ACCN2 Antibody//Human, Mouse,/Rabbit |
1/EA |
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문의 |
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Subject
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ACCN2 Antibody |
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Description
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/ Human, Mouse,/Rabbit |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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IHC-P, Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Hu, Mu, Rt | | Applications: | WB, IHC | | Clonality: | Polyclonal | | | Gene: | ACCN2 | | Purity: | Whole antisera | | Host: | Rabbit | | | Specificity: | ASIC1. | | Publications: | Antibody has not yet been mentioned in a publication. | Details: | Immunogen: | A synthetic peptide from the extracellular domain of rat amiloride sensitive cation channel 2, neuronal (ACCN2, ASIC1) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in mouse and shares 96% identity with human's. | Gene Symbol: ACCN2 | Entrez: | 41 (Human) | | | 11419 (Mouse) | | | 79123 (Rat) | | Swiss Prot: | P55926, Q6NXK8, A3KN86 (Human) | | Related Genes: | ACCN3, ACCN1, TRPV1, DRG, ACCN4, PICK1, S100A10, ANXA2, STX1A, GSTP1, TRPA1, PKC, PSMA7, GFAP, CA1, C6, HSPA8, NPVF, CFTR, P11, BNC1, FOS, P2RX3, EXOSC6, NPFF, MDEG1, MDEG2, RFC2, RFC1, MAPT, NTRK1, ATP6V0A1, RFC4, TAC1, CD19, CA3, INADL, AKAP150, PSD-95, CBX4 | Background: This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is expressed in most if not all brain neurons, and it may be an ion channel subunit; however, its function as an ion channel remains unknown.; FUNCTION: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+).; SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note=Localizes in synaptosomes at dendritic synapses of neurons.; TISSUE SPECIFICITY: Expressed in dorsal root ganglia (DRG) and sciatic nerve (at protein level). Widely distributed throughout the brain. Expressed in olfactory bulb, neo and allocortical regions, dentate granule cells, pyramidal cells of CA1-CA3 subfields of the hippocampal formation, habenula, basolateral amygdaloid nuclei, and in the Purkinje and granule cells of the cerebellum. Diffusely detected over most other regions of the basal ganglia, including thalamic nuclei, substantia nigra, striatum and globus pallidus, hypothalamus, midbrain, pons, medulla and choroid plexus. Isoform 3 is expressed only in dorsal root ganglion while isoform 1 is expressed in DRG, spinal chord, trigeminal ganglia and the trigeminal mesencephalic nucleus. Species: | Reactivity: | Rat, mouse, human. | Applications: | Uses: | Immunohistochemistry and Western Blot | | Dilutions: | immunohistochemistry,Western Blot 1:300 to 1:2000, | Notes: Reconstitute in 0.1 ml of sterile water. Centrifuge to remove any insoluble material. When reconstituting, glycerol (1:1) may be added for an additional stability. Packaging: | Buffer: | Lyophilized | | Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. | | Preservative: | No Preservative | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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