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Description |
Unit |
Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-356253 |
NBP1-04932 |
c Abl Antibody//Human, Mouse/Rabbit |
1/EA |
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문의 |
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Subject
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c Abl Antibody |
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Description
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/ Human, Mouse/Rabbit |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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IHC-P |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Mu, Hu | | Applications: | IHC | | Clonality: | Polyclonal | | | Gene: | ABL1 | | Purity: | Affinity purified | | Host: | Rabbit | | | Specificity: | ABL1/2 (Ab-393/429) detects endogenous levels of total ABL1/2 protein. | | Publications: | Antibody has not yet been mentioned in a publication. | Details: | Isotype: | IgG | | Immunogen: | The antiserum was produced against synthesized non-phosphopeptide derived from human ABL1/2 around the phosphorylation site of tyrosine 393/429 (D-T-Yp-T-A). | Gene Symbol: ABL1 | Entrez: | 25 (Human) | | | 11350 (Mouse) | | Swiss Prot: | P00519, P42684 (Human) | | Related Genes: | BCR, MTTP, ITGB2, SRC, ITGAL, TP53, ITGAM, MYC, ETV6, CD34, IL3, AKT1, CNTNAP1, KIT, PIK3CG, RUNX1, JAK2, LTBR, CDKN2A, EGFR, BCL2, ITGAX, MLL, BCL2L1, MAPK1, STAT5A, STAT5B, KITLG, PDGFRB, IL2, CDKN1A, PTK2B, EGF, ABI1, GRB2, NOL3, CRK, CR3, JUN, FOS | Background: The c Abl proto oncogene encodes a protein tyrosine kinase that is located in the cytoplasm and nucleus. In chronic myelogenous leukemia and in a subset of acute lymphoblastic leukemias, the c Abl proto oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome) As the result of the fusion of c Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The molecular consequence of this translocation is the generation of a chimeric Bcr/Abl mRNA encoding activated Abl protein tyrosine kinase.ABL2 (or ARG) is a nonreceptor cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of ABL1 and ABL2 includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is expressed in both normal and tumor cells. It is involved in translocation with the ETV6 gene in human leukemia and has an altered expression in several human carcinomas. Two isoforms of ABL2 with different N-termini (1A and 1B) have been identified. The C-terminal domain of ABL2 contains two F-actin-binding sequences that perform a number of actions related to cell morphology and motility by interacting with actin filaments. Species: | Reactivity: | This antibody is cross-reactive against Human, Mouse | Applications: | Uses: | This antibody is useful for immunohistochemistry 1:50-1:100 | | Dilutions: | immunohistochemistry 1:50-1:100, | | Concentrations: | 1.0 mg/ml | Packaging: | Buffer: | phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl and 50% glycerol. | | Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. | | Preservative: | 0.02% Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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