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Description |
Unit |
Price
(VAT별도) |
납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-356256 |
NBP1-19839 |
c Abl Antibody//Human, Mouse/Rabbit |
1/EA |
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문의 |
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Subject
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c Abl Antibody |
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Description
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/ Human, Mouse/Rabbit |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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IHC-P, Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Mu, Hu | | Applications: | IHC, WB | | Clonality: | Polyclonal | | | Gene: | ABL1 | | Purity: | Affinity purified | | Host: | Rabbit | | | Specificity: | c-Abl (L406) detects endogenous levels of c-Abl protein. | Details: Gene Symbol: ABL1 | Entrez: | 25 (Human) | | Related Genes: | BCR, MTTP, ITGB2, SRC, ITGAL, TP53, ITGAM, MYC, ETV6, CD34, IL3, AKT1, CNTNAP1, KIT, PIK3CG, RUNX1, JAK2, LTBR, CDKN2A, EGFR, BCL2, ITGAX, MLL, BCL2L1, MAPK1, STAT5A, STAT5B, KITLG, PDGFRB, IL2, CDKN1A, PTK2B, EGF, ABI1, GRB2, NOL3, CRK, CR3, JUN, FOS | Background: The Abl oncogene was initially identified as the viral transforming gene ofAbelson murine leukemia virus (A-MuLV). The major translational product ofc-Abl has been identified as a protein with tyrosine kinase activity and an SH2domain. The Abl oncogene is implicated in several human leukemias including90-95% of chronic myelocytic leukemia (CML), 20-25% of adult acute lymphoblasticleukemia (ALL) and 2-5% of pediatric ALL. In these leukemias thec-Abl proto-oncogene undergoes a (9;22) chromosomal translocation producingthe Philadelphia (Ph1) chromosome. The molecular consequence of this translocationis the generation of a chimeric Bcr/c-Abl mRNA encoding activatedAbl protein-tyrosine kinase. The Bcr gene has been shown to encode aGTPase-activating protein (GAP) specific for the Ras-related GTP-bindingprotein, p21rac. Species: Applications: | Uses: | This antibody is useful for Western Blot and Immunohistochemistry.Western blot analyzes of c-Abl (L406) antibody in extracts from RAW264.7 cells.Immunohistochemistry analyzes of c-Abl (L406) antibody in paraffin-embedded human breast carcinoma tissue. | | Dilutions: | Western Blot 1:500-1:1000,immunohistochemistry 1:50-1:200, | Packaging: | Buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2. | | Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. | | Preservative: | No Preservative | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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